Evidence map›Paper›PMID 29861916›Full record

ArticleChemical science2015

H-Rubies, a new family of red emitting fluorescent pH sensors for living cells.

Guillaume Despras, Alsu I Zamaleeva, Lucie Dardevet, Céline Tisseyre, Joao Gamelas Magalhaes, Charlotte Garner, Michel De Waard, Sebastian Amigorena, Anne Feltz, Jean-Maurice Mallet and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Guillaume DesprasLaboratory of Biomolecules (LBM) , UPMC Université Paris 06 , Ecole Normale Supérieure (ENS) , CNRS, UMR 7203 , Paris F-75005 , France . Email: mayeul.collot@unistra.fr.
Alsu I ZamaleevaEcole Normale Supérieure , Institut de Biologie de l'ENS (IBENS) , INSERM U1024 , CNRS UMR 8197 , Paris F-75005 , France.
Lucie DardevetInserm U836 , LabEx Ion Channels, Science and Therapeutics , Grenoble Institute of Neuroscience , chemin fortuné ferrini, bâtiment Edmond Safra , 38042 Grenoble Cedex 09 , France.
Céline TisseyreInserm U836 , LabEx Ion Channels, Science and Therapeutics , Grenoble Institute of Neuroscience , chemin fortuné ferrini, bâtiment Edmond Safra , 38042 Grenoble Cedex 09 , France.
Joao Gamelas MagalhaesINSERM U932 , Institute Curie , 75248 , Paris, Cedex 05 , France.
Charlotte GarnerLaboratory of Biomolecules (LBM) , UPMC Université Paris 06 , Ecole Normale Supérieure (ENS) , CNRS, UMR 7203 , Paris F-75005 , France . Email: mayeul.collot@unistra.fr.
Michel De WaardInserm U836 , LabEx Ion Channels, Science and Therapeutics , Grenoble Institute of Neuroscience , chemin fortuné ferrini, bâtiment Edmond Safra , 38042 Grenoble Cedex 09 , France.ORCID 0000-0002-2782-9615
Sebastian AmigorenaINSERM U932 , Institute Curie , 75248 , Paris, Cedex 05 , France.
Anne FeltzEcole Normale Supérieure , Institut de Biologie de l'ENS (IBENS) , INSERM U1024 , CNRS UMR 8197 , Paris F-75005 , France.
Jean-Maurice MalletLaboratory of Biomolecules (LBM) , UPMC Université Paris 06 , Ecole Normale Supérieure (ENS) , CNRS, UMR 7203 , Paris F-75005 , France . Email: mayeul.collot@unistra.fr.ORCID 0000-0001-8570-9542
Mayeul CollotLaboratory of Biomolecules (LBM) , UPMC Université Paris 06 , Ecole Normale Supérieure (ENS) , CNRS, UMR 7203 , Paris F-75005 , France . Email: mayeul.collot@unistra.fr.ORCID 0000-0002-8673-1730
Inserm · FRCentre National de la Recherche Scientifique · FR

Funding

European Research Council 340046
6 · The paper itself

Abstract

Monitoring intracellular pH has drawn much attention due to its undeniably important function in cells. The widespread development of fluorescent imaging techniques makes pH sensitive fluorescent dyes valuable tools, especially red-emitting dyes which help to avoid the overcrowded green end of the spectral band. Herein, we present H-Rubies, a family of pH sensors based on a phenol moiety and a X-rhodamine fluorophore that display a bright red fluorescence upon acidification with p

Identifiers

PMID29861916
PMCPMC5950754
OpenAlexW1785714480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.