Evidence map›Paper›PMID 29861798›Full record

ArticleAsian biomedicine : research, reviews and news2017

Thai national guidelines for the prevention of mother-to-child transmission of human immunodeficiency virus 2017.

Rangsima Lolekha, Kulkanya Chokephaibulkit, Nittaya Phanuphak, Surasith Chaithongwongwatthana, Sasisopin Kiertiburanakul, Pleonchan Chetchotisakd, Sarawut Boonsuk, Thai national prevention of mother-to-child transmission (PMTCT) Guidelines Working Group

Open access · greenAbstract read
In one paragraph

Article in Asian biomedicine : research, reviews and news, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Rangsima LolekhaDivision of Global HIV and TB, Thailand Ministry of Public Health - U.S. CDC Collaboration, Nonthaburi 11000, Thailand.
Kulkanya ChokephaibulkitDepartment of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Nittaya PhanuphakThe Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
Surasith ChaithongwongwatthanaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Sasisopin KiertiburanakulDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Pleonchan ChetchotisakdDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Sarawut BoonsukDepartment of Health, Thailand Ministry of Public Health, Nonthaburi 11000, Thailand.
Thai national prevention of mother-to-child transmission (PMTCT) Guidelines Working Group
Chulalongkorn University · THKhon Kaen University · THMahidol University · THRamathibodi Hospital · THThai Red Cross Society · TH

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundThailand has made progress in reducing perinatal HIV transmission rates to levels that meet the World Health Organization targets for so-called "elimination" (<2%) of mother-to-child transmission (MTCT).

objectivesTo highlight the Thailand National Guidelines on HIV/AIDS Treatment Prevention Working Group issued a new version of its National Prevention of MTCT guidelines in March 2017 aimed to reduce MTCT rate to <1% by 2020. DISCUSSION OF GUIDELINES: The guidelines include recommending initiation of antepartum antiretroviral therapy (ART) containing tenofovir disoproxil fumarate (TDF) plus lamivudine (3TC)/emtricitabine (FTC) plus efavirenz regardless of CD4 cell count as soon as HIV is diagnosed for ART naïve HIV-infected pregnant women. An alternative regimen is TDF or zidovudine (AZT) plus 3TC/FTC plus lopinavir/ritonavir (LPV/r) for HIV-infected pregnant women suspected resistant to non-nucleoside reverse transcriptase inhibitors. Treatment should be started immediately irrespective of gestational age and continued after delivery for life. Raltegravir is recommended in addition to the ART regimen for HIV-infected pregnant women who present late (gestational age (GA) ≥32 weeks) or those who have a viral load (VL) >1000 copies/mL at GA ≥32 weeks. HIV-infected pregnant women who conceive while receiving ART should continue their treatment regimen during pregnancy. HIV-infected pregnant women who present in labor and are not receiving ART should receive single-dose nevirapine immediately along with oral AZT, and continue ART for life. Infants born to HIV-infected mothers are categorized as high or standard risk for MTCT. High MTCT risk is defined as an infant whose mother has a viral load (VL) > 50 copies/mL at GA > 36 weeks or has received ART <12 weeks before delivery, or has poor ART adherence. These infants should be started on AZT plus 3TC plus NVP for 6 weeks after delivery. Infants with standard MTCT risk should receive AZT for 4 weeks. Formula feeding exclusively is recommended for all HIV-exposed infants.

Indexed as

GuidelinesHIVmother-to-child transmissionThailand

Identifiers

PMID29861798
PMCPMC5978732
OpenAlexW2613484671

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.