ArticleJournal of pharmaceutical health services research : an official journal of the Royal Pharmaceutical Society of Great Britain2018
Estimation of Quality-adjusted Life Years alongside clinical trials: the impact of 'time-effects' on trial results.
Article in Journal of pharmaceutical health services research : an official journal of the Royal Pharmaceutical Society of Great Britain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Cost-Effectiveness of Stepped Care Versus Stratified Care for Pediatric Anxiety Disorders: A Pilot Evaluation in Routine Care.Child psychiatry and human development · 2026Article
- Health utility adjusted survival: A composite endpoint for clinical trial designs.Statistical methods in medical research · 2025Article
- Health Utility Survival for Randomized Clinical Trials: Extensions and Statistical Properties.Statistics in medicine · 2025Article
- Heart Rehabilitation for All (HeRTA): Protocol for a feasibility study and pilot randomized trial.PloS one · 2022Article
- Evaluation of a novel strategy to implement exercise evidence into clinical practice in breast cancer care: protocol for the NEXT-BRCA randomised controlled trial.BMJ open sport & exercise medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objectives were to investigate the impact of 'time-effect' on the estimation of quality-adjusted life years (QALYs) along prospective clinical trials' outcomes using an assumed fixed time duration versus the actual time durations for each case. The 'time' duration is the length of time in a health state.
methodsTwo methods were used in the estimation of QALYs based using EQ-5D 3L scores collected at specific time-point intervals. One method used the actual time durations for each case based on CRF records, and the other used an assumed time duration and globally applied it to all the cases. Using SPSS KEY
findingsThe results largely indicate statistically significant differences between the two methods of QALY estimations. QALYs at the respective time-points indicate no statistical difference between the two approaches. However, the difference in terms of total QALYs between the two QALY estimation approaches is statistically significant with considerable impact on costs/QALY.
conclusionsConsidering the possible impact of the time-effect on QALY estimations, the result implies that it can have significant implications for resources allocations decisions. In this respect, researchers have to pay due considerations to the approach they use and where possible, actual time durations must be used in QALY estimations along prospective clinical trials.
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Registered trials
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