Evidence map›Paper›PMID 29861739›Full record

ArticleStem cells international2018

Evaluation of the Curative Effect of Umbilical Cord Mesenchymal Stem Cell Therapy for Knee Arthritis in Dogs Using Imaging Technology.

Bei-Ying Zhang, Bing-Yun Wang, Shao-Chuan Li, Dong-Zhang Luo, Xiaoshu Zhan, Sheng-Feng Chen, Zhi-Sheng Chen, Can-Ying Liu, Hui-Qin Ji, Yin-Shan Bai and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
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  7. Article
  8. Article
  9. Review
  10. Wharton's jelly and osteoarthritis of the knee.British medical bulletin · 2024
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Articular Cartilage Regeneration in Veterinary Medicine.Advances in experimental medicine and biology · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Bei-Ying ZhangSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Bing-Yun WangSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.ORCID 0000-0002-7472-1084
Shao-Chuan LiSchool of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Dong-Zhang LuoSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Xiaoshu ZhanSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Sheng-Feng ChenSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Zhi-Sheng ChenSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Can-Ying LiuSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Hui-Qin JiSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Yin-Shan BaiSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Dong-Sheng LiSchool of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Yang HeThai Yang Animal Hospital, Guangzhou 510000, China.
Foshan University · CNSouth China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to assess the efficacy of canine umbilical cord mesenchymal stem cells (UC-MSCs) on the treatment of knee osteoarthritis in dogs.

methodsEight dogs were evenly assigned to two groups. The canine model of knee osteoarthritis was established by surgical manipulation of knee articular cartilage on these eight dogs. UC-MSCs were isolated from umbilical cord Wharton's jelly by 0.1% type collagenase I and identified by immunofluorescence staining and adipogenic and osteogenic differentiation

resultsResults revealed that the isolated cells were UC-MSCs, because they were positive for CD44 and negative for CD34 surface markers, and the cells were differentiated into adipocytes and osteoblasts. Imaging technology showed that as treatment time increased, the high signal in the MRI T2-weighted images decreased, the echo-free space in B ultrasonography images disappeared basically, and the continuous linear hypoechoic region at the trochlear sulcus thickened. On X-ray images, the serrate defect at the ventral cortex of the patella improved, and the low-density gap of the ventral patella and trochlear crest gradually increased in the treated group. On the contrary, the high signal in the MRI T2-weighted images and the echo-free space in B ultrasonography images still increased after a 14-day treatment in the untreated control group, and the linear hypoechoic region was discontinuous. On the X-ray images, there was no improvement in the serrate defect of the ventral cortex of the patella. Results for inflammatory factors showed that the blood levels of IL-6, IL-7, and TNF-

conclusionSignificantly higher improvement in cartilage neogenesis and recovery was observed in the treated group compared to the untreated control group. The joint fluid and the inflammatory response in the treated group decreased. Moreover, improved recovery in the neogenetic cartilage, damaged skin fascia, and muscle tissue around the joints was more significant in the treated group than in the untreated control group. In conclusion, canine UC-MSCs promote the repair of cartilage and patella injury in osteoarthritis, improve the healing of the surrounding tissues, and reduce the inflammatory response.

Identifiers

PMID29861739
PMCPMC5976915
OpenAlexW2804458415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.