ArticleInternational journal of analytical chemistry2018
Development and Validation of a Simple High Performance Liquid Chromatography/UV Method for Simultaneous Determination of Urinary Uric Acid, Hypoxanthine, and Creatinine in Human Urine.
Article in International journal of analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Non-invasive monitoring of hyperuricemia via a flexible SERS sensor with ultrahigh sensitivity.Mikrochimica acta · 2026Article
- Pencil-Drawn Electrode within Additively Manufactured Devices for Uric Acid Detection.ACS omega · 2026Article
- Article
- A Review on Optical Biosensors for Monitoring of Uric Acid and Blood Glucose Using Portable POCT Devices: Status, Challenges, and Future Horizons.Biosensors · 2025Review
- Article
- Smartphone based colorimetric approach for quantitative determination of uric acid using Image J.Scientific reports · 2023Article
- Using Urinary Biomarkers to Estimate the Benzene Exposure Levels in Individuals Exposed to Benzene.Toxics · 2022Article
- Optimization of uric acid detection with Au nanorod-decorated graphene oxide (GO/AuNR) using response surface methodology.RSC advances · 2022Article
- Effect of acrolein, a lipid oxidation product, on the formation of the heterocyclic aromatic amine 2-amino-1-methyl-6-phenylimidazo[4,5-Food chemistry: X · 2022Article
- Noninvasive and Individual-Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Pentacyanoammineferrate-Based Non-Enzymatic Electrochemical Biosensing Platform for Selective Uric Acid Measurement.Sensors (Basel, Switzerland) · 2021Article
- An Advanced Statistical Approach Using Weighted Linear Regression in Electroanalytical Method Development for Epinephrine, Uric Acid and Ascorbic Acid Determination.Sensors (Basel, Switzerland) · 2020Article
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Authors and funding
4 authors.
Funding
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Abstract
Uric acid and hypoxanthine are produced in the catabolism of purine. Abnormal urinary levels of these products are associated with many diseases and therefore it is necessary to have a simple and rapid method to detect them. Hence, we report a simple reverse phase high performance liquid chromatography (HPLC/UV) technique, developed and validated for simultaneous analysis of uric acid, hypoxanthine, and creatinine in human urine. Urine was diluted appropriately and eluted with C-18 column 100 mm × 4.6 mm with a C-18 precolumn 25 mm × 4.6 mm in series. Potassium phosphate buffer (20 mM, pH 7.25) at a flow rate of 0.40 mL/min was employed as the solvent and peaks were detected at 235 nm. Tyrosine was used as the internal standard. The experimental conditions offered a good separation of analytes without interference of endogenous substances. The calibration curves were linear for all test compounds with a regression coefficient,
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