ArticleInternational journal of nanomedicine2018
Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI.
Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Patient-specific estimation of distal lung morphometry using aerosol deposition data.Frontiers in physiology · 2025Article
- Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests.International journal of nanomedicine · 2022Article
- Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema.Thorax · 2021Article
- Airspace Dimension Assessment (AiDA) by inhaled nanoparticles: benchmarking with hyperpolarisedScientific reports · 2021Article
- Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAirspace Dimension Assessment with inhaled nanoparticles is a novel method to determine distal airway morphology. This is the first empirical study using Airspace Dimension Assessment with nanoparticles (AiDA) to estimate distal airspace radius. The technology is relatively simple and potentially accessible in clinical outpatient settings.
methodNineteen never-smoking volunteers performed nanoparticle inhalation tests at multiple breath-hold times, and the difference in nanoparticle concentration of inhaled and exhaled gas was measured. An exponential decay curve was fitted to the concentration of recovered nanoparticles, and airspace dimensions were assessed from the half-life of the decay. Pulmonary tissue density was measured using magnetic resonance imaging (MRI).
resultsThe distal airspace radius measured by AiDA correlated with lung tissue density as measured by MRI (
conclusionThe AiDA method shows potential to be developed into a tool to assess conditions involving changes in distal airways, eg, emphysema. The intercept may reflect airway properties; this finding should be further investigated.
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Registered trials
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