Evidence map›Paper›PMID 29861287›Full record

ArticleNeuron2018

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

Yuan-Ta Lin, Jinsoo Seo, Fan Gao, Heather M Feldman, Hsin-Lan Wen, Jay Penney, Hugh P Cam, Elizabeta Gjoneska, Waseem K Raja, Jemmie Cheng and 11 more

Erratum issuedOpen access · bronzeAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 618 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
618citing papers in PubMed, 2 pooled it
36.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

618 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,120 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  7. Using Brain Organoids to Explore Human Neurobiology.Cellular and molecular neurobiology · 2026
    Review
  8. Human iPSC models revealResearch square · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
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558 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Yuan-Ta LinPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jinsoo SeoPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Fan GaoPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Heather M FeldmanDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Hsin-Lan WenPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jay PenneyPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Hugh P CamPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Elizabeta GjoneskaPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Waseem K RajaPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jemmie ChengPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Richard RuedaPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Oleg KritskiyPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Fatema AbdurrobPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Zhuyu PengPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Blerta MiloPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chung Jong YuPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard University, John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA.
Sara ElmsaouriPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Dilip DeyPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tak KoPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Bruce A YanknerDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Li-Huei TsaiPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: lhtsai@mit.edu.
Massachusetts Institute of Technology · USHarvard University · US

Funding

Exploring a Novel Paradigm of Schizophrenia and Bipolar DisorderR01MH113279 · NIMH · HARVARD MEDICAL SCHOOL · PI CHURCH, GEORGE M, YANKNER, BRUCE A · 2016 to 2020
$4.7M
Alzheimer's Disease Risk Genes in Human Microglia and Neurons Derived from iPSCsRF1AG048029 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSAI, LI-HUEI · 2014 to 2014
$2.1M
Genome Engineering an IPSC Model of Alzheimer's DiseaseRF1AG048056 · NIA · HARVARD MEDICAL SCHOOL · PI CHURCH, GEORGE M, YANKNER, BRUCE A · 2014 to 2014
$2.1M
Epigenetic Analysis of iPS Cell Models of Aging and Alzheimer's DiseaseRC1AG036106 · NIA · HARVARD MEDICAL SCHOOL · PI YANKNER, BRUCE A · 2009 to 2010
$1.0M
NIA NIH HHS RC1 AG036106NIA NIH HHS RF1 AG048029NIA NIH HHS RF1 AG048056NIMH NIH HHS R01 MH113279
6 · The paper itself

Abstract

The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in relation to AD pathology remain understudied. Here, we utilize CRISPR/Cas9 and induced pluripotent stem cells (iPSCs) to examine APOE4 effects on human brain cell types. Transcriptional profiling identified hundreds of differentially expressed genes in each cell type, with the most affected involving synaptic function (neurons), lipid metabolism (astrocytes), and immune response (microglia-like cells). APOE4 neurons exhibited increased synapse number and elevated Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesApolipoprotein E3Apolipoprotein E4AstrocytesBrainCell DifferentiationCRISPR-Cas SystemsHumansInduced Pluripotent Stem CellsLipid MetabolismMicrogliaNeurogliaNeuronsOrganoidsPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)Apolipoprotein E3Apolipoprotein E4MAPT protein, humanPeptide FragmentsPhosphoproteinstau ProteinsAlzheimer’s diseaseAPOEAβAβ uptakecerebral organoidscholesterolCRISPR/Cas9early endosomesimmune responseiPSC

Identifiers

PMID29861287
PMCPMC6023751
OpenAlexW2805798400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.