Evidence map›Paper›PMID 29860868›Full record

ArticleAIDS research and human retroviruses2018

Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut.

Sallie Permar, Ofer Levy, Tobias R Kollman, Anjali Singh, Kristina De Paris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sallie Permar1 Department of Pediatrics, Duke University Medical School , Durham, North Carolina.
Ofer Levy3 Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital , Boston, Massachusetts.
Tobias R Kollman6 Division of Infectious Diseases, Department of Pediatrics, University of British Columbia , Vancouver, Canada .
Anjali Singh7 Vaccine Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, Maryland.
Kristina De Paris8 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.

Funding

Project 2: RNA vaccination in early life to induce potent and broad HIV Env-specific antibody responsesP01AI117915 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE PARIS, KRISTINA, PERMAR, SALLIE R. · 2015 to 2024
$21.2M
NIAID NIH HHS P01 AI117915
6 · The paper itself

Abstract

Limited success of current HIV-1 vaccines warrants new approaches. We discuss feasibility and potential benefits of early life HIV-1 immunization followed by vaccine boosts during childhood that may enable maturation of vaccine-induced broad anti-HIV-1 immunity over several years. By initiating this immunization approach in the very young, well before sexual debut, such a strategy may dramatically reduce the risk of HIV-1 infection.

Indexed as

Age FactorsAIDS VaccinesAnimalsDisease Models, AnimalHIV-1HIV AntibodiesHIV InfectionsHumansImmunizationInfantInfant, NewbornYoung AdultAIDS VaccinesHIV AntibodiesHIV preventionimmune developmentvaccine

Identifiers

PMID29860868
PMCPMC6204561

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.