ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019
A longitudinal study of muscle strength and function in patients with cancer cachexia.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Exercise as supportive care in advanced cancer-related weight loss: a feasibility study comparing patients with and without severe weight loss.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Prognostic Impact of Cachexia in Patients Undergoing Radical Resection for Colorectal Cancer: A Retrospective Study.Journal of gastrointestinal cancer · 2025Article
- Exploration of Fully-Automated Body Composition Analysis Using Routine CT-Staging of Lung Cancer Patients for Survival Prognosis.Journal of cachexia, sarcopenia and muscle · 2025Article
- Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers.Cancers · 2024Review
- Phenotypic features of cancer cachexia-related loss of skeletal muscle mass and function: lessons from human and animal studies.Journal of cachexia, sarcopenia and muscle · 2021Review
- Article
- Deterioration in Muscle Mass and Physical Function Differs According to Weight Loss History in Cancer Cachexia.Cancers · 2019Article
- Understanding sex differences in the regulation of cancer-induced muscle wasting.Current opinion in supportive and palliative care · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposePatients with cancer frequently experience an involuntary loss of weight (in particular loss of muscle mass), defined as cachexia, with profound implications for independence and quality of life. The rate at which such patients' physical performance declines has not been well established. The aim of this study was to determine the change in muscle strength and function over 8 weeks in patients with already established cancer cachexia, to help inform the design and duration of physical activity interventions applicable to this patient group.
methodsPatients with thoracic and gastrointestinal cancer and with unintentional weight loss of > 5% in 6 months or BMI < 20 plus 2% weight loss were included. Physical and functional assessments (baseline, 4 weeks, 8 weeks) included isometric quadriceps and hamstring strength, handgrip, standing balance, 10-m walk time and timed up and go.
resultsFifty patients (32 male), mean ± SD age 65 ± 10 years and BMI 24.9 ± 4.3 kg/m
conclusionsMore than a third of patients with established cancer cachexia in our study were stable over 8 weeks, suggesting a subgroup who may benefit from targeted interventions of reasonable duration. Better understanding the physical performance parameters which characterise and differentiate these patients has important clinical implications for cancer multidisciplinary team practice.
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Registered trials
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