Trial reportJournal of neurology2018
Fatigue, not self-rated motor symptom severity, affects quality of life in functional motor disorders.
Trial report in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Pain and functional neurological disorder: a systematic review and meta-analysis.Journal of neurology, neurosurgery, and psychiatry · 2024Pooled it
- Pooled it
- Outcome measurement in functional neurological disorder: a systematic review and recommendations.Journal of neurology, neurosurgery, and psychiatry · 2020Pooled it
- Diagnostic Overshadowing in Functional Neurological Disorder Leading to a Diagnosis of Acute Motor and Sensory Axonal Neuropathy: A Case Report.Journal of clinical medicine · 2026Article
- Clinical features of adolescent-onset functional motor disorders in tertiary movement disorders centers.Journal of neurology · 2026Observational
- Article
- Self-Reported Motor and Non-Motor Symptoms in People With Functional Gait Disorder: A Cross-Sectional Study.Brain and behavior · 2025Article
- The relationship between self-rated health and occupational accidents: a nationwide prospective cohort study.Journal of occupational health · 2025Article
- Predictive Processing and the Pathophysiology of Functional Neurological Disorder.Current topics in behavioral neurosciences · 2025Review
- Positive signs from the history as an aid for early diagnosis in functional movement disorders: The prospective TASMAN study.European journal of neurology · 2025Article
- [Understanding and explaining functional movement disorders].Der Nervenarzt · 2024Review
- Efficacy of Hypnosis and Catalepsy Induction in Functional Neurological Disorders.Movement disorders clinical practice · 2024Article
- Cross-sectional evaluation of health resource use in patients with functional neurological disorders referred to a tertiary neuroscience centre.BMJ neurology open · 2024Article
- Elderly Onset of Functional Motor Disorders: Clinical Correlates from the Italian Registry.Movement disorders clinical practice · 2024Article
- Outpatient Motor Retraining for Functional Movement Disorder: Predictors of a Favorable Short-Term Response.Movement disorders clinical practice · 2023Article
- Why functional neurological disorder is not feigning or malingering.Nature reviews. Neurology · 2023Review
- Hazard Perception Skill and Driver Behavior in Patients With Functional Neurologic Disorders.Neurology · 2023Article
- Improvement in motor symptoms, physical fatigue, and self-rated change perception in functional motor disorders: a prospective cohort study of a 12-week telemedicine program.Journal of neurology · 2022Article
- [Development and content validation of a questionnaire for functional movement disorders].Der Nervenarzt · 2022Article
- A new science of emotion: implications for functional neurological disorder.Brain : a journal of neurology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
While fatigue is found to be an impairing symptom in functional motor disorders (FMD) in clinical practice, scientific evidence is lacking. We investigated fatigue severity and subtypes in FMD compared to organic neurological disease. Furthermore, the role of fatigue within FMD and its impact on quality of life and self-rated health were investigated. Data from 181 patients participating in the self-help on the internet for functional motor disorders, randomised Trial were included. Data from 217 neurological controls with neuromuscular disorders (NMD) originated from a historical cohort. Fatigue was measured using the checklist individual strength (CIS). Motor symptom severity, depression and anxiety were correlated to fatigue. For multivariable regression analyses, physical functioning and pain were additionally taken into account. Severe fatigue was, respectively, present in 78 and 53% of FMD and NMD patients (p < 0.001). FMD patients scored higher than NMD patients on all fatigue subdomains (p < 0.001). In the FMD group, fatigue subdomains were correlated to depression, anxiety and partly to motor symptom severity. Quality of life was negatively associated with fatigue [OR 0.93 (0.90-0.96), p < 0.001] and depression [OR 0.87 (0.81-0.93), p < 0.001], but not self-rated motor symptom severity. Self-rated health was negatively associated with fatigue [OR 0.92 (0.88-0.96), p < 0.001] and pain [OR 0.98 (0.97-0.99), p < 0.001]. Fatigue was found to be a prevalent problem in FMD, more so than in organic neurological disease. It significantly affected quality of life and self-rated health, while other factors such as motor symptom severity did not. Fatigue should be taken into account in clinical practice and treatment trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.