ArticleMicrobial ecology2019
Discovery of a Novel Periodontal Disease-Associated Bacterium.
Article in Microbial ecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- The Effect ofPolish journal of microbiology · 2020Trial
- Study of oral microbiome by next generation sequencing in T1DM adolescents with periodontal disease.Acta diabetologica · 2026Article
- Association Between Periodontal Pathogens and Inflammation in Patients with Acute Coronary Syndromes.International journal of molecular sciences · 2025Article
- Microbiological and molecular aspects of periodontitis pathogenesis: an infection-induced inflammatory condition.Frontiers in cellular and infection microbiology · 2025Review
- Relationship Between the Presence of Red Complex Species and the Distribution of Other Oral Bacteria, Including Major Periodontal Pathogens in Older Japanese Individuals.International journal of molecular sciences · 2024Article
- Data-driven mathematical and visualization approaches for removing rare features for Compositional Data Analysis (CoDA).NAR genomics and bioinformatics · 2024Article
- Illuminating the oral microbiome and its host interactions: recent advancements in omics and bioinformatics technologies in the context of oral microbiome research.FEMS microbiology reviews · 2023Review
- The use of mucoadhesive oral patches containing epigallocatechin-3-gallate to treat periodontitis: an in vivo study.Journal of Taibah University Medical Sciences · 2022Article
- The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions.Frontiers in microbiology · 2022Review
- Comparison of three qPCR-based commercial tests for detection of periodontal pathogens.Scientific reports · 2021Article
- Metagenomic and Metatranscriptomic Insight Into Oral Biofilms in Periodontitis and Related Systemic Diseases.Frontiers in microbiology · 2021Review
- Compositional Data Analysis of Periodontal Disease Microbial Communities.Frontiers in microbiology · 2021Article
- Grade C molar-incisor pattern periodontitis subgingival microbial profile before and after treatment.Journal of oral microbiology · 2020Article
- Rapamycin rejuvenates oral health in aging mice.eLife · 2020Article
- Red complex: Polymicrobial conglomerate in oral flora: A review.Journal of family medicine and primary care · 2019Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
One of the world's most common infectious disease, periodontitis (PD), derives from largely uncharacterized communities of oral bacteria growing as biofilms (a.k.a. plaque) on teeth and gum surfaces in periodontal pockets. Bacteria associated with periodontal disease trigger inflammatory responses in immune cells, which in later stages of the disease cause loss of both soft and hard tissue structures supporting teeth. Thus far, only a handful of bacteria have been characterized as infectious agents of PD. Although deep sequencing technologies, such as whole community shotgun sequencing have the potential to capture a detailed picture of highly complex bacterial communities in any given environment, we still lack major reference genomes for the oral microbiome associated with PD and other diseases. In recent work, by using a combination of supervised machine learning and genome assembly, we identified a genome from a novel member of the Bacteroidetes phylum in periodontal samples. Here, by applying a comparative metagenomics read-classification approach, including 272 metagenomes from various human body sites, and our previously assembled draft genome of the uncultivated Candidatus Bacteroides periocalifornicus (CBP) bacterium, we show CBP's ubiquitous distribution in dental plaque, as well as its strong association with the well-known pathogenic "red complex" that resides in deep periodontal pockets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.