Evidence map›Paper›PMID 29860628›Full record

ArticleDiabetologia2018

Cognitive function in early and later life is associated with blood glucose in older individuals: analysis of the Lothian Birth Cohort of 1936.

Drew M Altschul, John M Starr, Ian J Deary

Abstract read
In one paragraph

Article in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The association between diabetes and cognitive changes during aging.Scandinavian journal of primary health care · 2020
    Pooled it
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  11. Intelligence, health and death.Nature human behaviour · 2021
    Review
  12. Article
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  14. Playing Analog Games Is Associated With Reduced Declines in Cognitive Function: A 68-Year Longitudinal Cohort Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Drew M AltschulDepartment of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK. drew.altschul@ed.ac.uk.ORCID http://orcid.org/0000-0001-7053-4209
John M StarrDepartment of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Ian J DearyDepartment of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.

Funding

Medical Research Council MR/K026992/1Medical Research Council MR/M013111/1
6 · The paper itself

Abstract

aims/hypothesisThe aim of this study was to examine whether cognitive function in early and later life, and decline in cognitive function from age 70 to 79 years, are associated with high blood glucose, as measured by HbA

methodsParticipants (n = 1091) in the Lothian Birth Cohort of 1936 were examined. Fourteen tests were used to assess cognitive functions, grouped into four domains: visuospatial ability, processing speed, memory and crystallised ability. Test results, and measurements of HbA

resultsHigher age 11 cognitive function predicted lower HbA CONCLUSIONS/

interpretationOur results show that, among older individuals, high blood glucose is consistently predicted by lower cognitive function. Clinical care that examines and tracks cognitive function, while also taking the positive effects of maintaining cognitive function and emulating healthy behaviours associated with higher cognitive function into account, may be one approach for protecting at-risk individuals from elevated blood glucose and subsequent type 2 diabetes mellitus.

Indexed as

AgedBlood GlucoseBody Mass IndexCognitionCognition DisordersCohort StudiesDiabetes Mellitus, Type 2Disease ProgressionFemaleGlycated HemoglobinHumansMaleNeuropsychological TestsUnited KingdomBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanBlood glucoseCognitive declineCognitive functionHbA1cOlder ageType 2 diabetes

Identifiers

PMID29860628
PMCPMC6096629

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.