ReviewPain and therapy2018
A Review of the Burden of Trauma Pain in Emergency Settings in Europe.
Review in Pain and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of opioids for traumatic pain in the emergency department: a systematic review and Bayesian network meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Evaluation of the effectiveness and costs of inhaled methoxyflurane versus usual analgesia for prehospital injury and trauma: non-randomised clinical study.BMC emergency medicine · 2022Trial
- Trial
- Prospective, Multicentre Trial of Methoxyflurane for Acute Trauma-Related Pain in Helicopter Emergency Medical Systems and Hostile Environments: METEORA Protocol.Advances in therapy · 2018Trial
- The assessment and management of acute trauma pain in a Cape Town, South Africa Emergency Centre: A retrospective chart review.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2026Article
- Pain management of adults in the prehospital setting: a scoping review.BMC emergency medicine · 2026Article
- Pre- and postoperative pain management practices in fracture surgery: A bicentric prospective observational study in Ethiopia.Langenbeck's archives of surgery · 2025Observational
- Optimizing acute pain management in trauma care: the role, structure and core principles of acute trauma pain services.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Review
- Analgesic Therapy with the Opioids Fentanyl and Morphine by Ambulance Personnel in Rural Areas: An Observational Study Over 7 Years.Journal of pain research · 2024Article
- Application of analgesics in emergency services in Germany: a survey of the medical directors.BMC emergency medicine · 2023Article
- [Practice of perioperative phantom limb pain prevention in Germany: a nationwide survey].Die Anaesthesiologie · 2022Article
- Low-Dose Methoxyflurane versus Standard of Care Analgesics for Emergency Trauma Pain: A Systematic Review and Meta-Analysis of Pooled Data.Journal of pain research · 2021Article
- Prehospital management of burns requiring specialized burn centre evaluation: a single physician-based emergency medical service experience.Scandinavian journal of trauma, resuscitation and emergency medicine · 2020Article
- Intravenous versus oral paracetamol in a UK ambulance service: a case control study.British paramedic journal · 2020Article
- Article
- Inhaled Methoxyflurane versus Intravenous Morphine for Severe Trauma Pain in the Emergency Setting: Subgroup Analysis of MEDITA, a Multicenter, Randomized, Controlled, Open-Label Trial.Journal of pain research · 2020Article
- Article
- Methoxyflurane Versus Standard of Care for Acute Trauma-Related Pain in the Emergency Setting: Protocol for a Randomised, Controlled Study in Italy (MEDITA).Advances in therapy · 2019Article
- Evaluation of pain relief treatment and timelines in emergency care in six European countries and Australia.Open access emergency medicine : OAEM · 2019Article
- The role of inhaled methoxyflurane in acute pain management.Open access emergency medicine : OAEM · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trauma pain represents a large proportion of admissions to emergency departments across Europe. There is currently an unmet need in the treatment of trauma pain extending throughout the patient journey in emergency settings. This review aims to explore these unmet needs and describe barriers to the delivery of effective analgesia for trauma pain in emergency settings. A comprehensive, qualitative review of the literature was conducted using a structured search strategy (Medline, Embase and Evidence Based Medicine Reviews) along with additional Internet-based sources to identify relevant human studies published in the prior 11 years (January 2006-December 2017). From a total of 4325 publications identified, 31 were selected for inclusion based on defined criteria. Numerous barriers to the effective treatment of trauma pain in emergency settings were identified, which may be broadly defined as arising from a lack of effective pain management pan-European and national guidelines, delayed or absent pain assessment, an aversion to opioid analgesia and a delay in the administration of analgesia. Several commonly used analgesics also present limitations in the treatment of trauma pain due to the routes of administration, adverse side effect profiles, pharmacokinetic properties and suitability for use in pre-hospital settings. These combined barriers lead to the inadequate and ineffective treatment of trauma pain for patients. An unmet need therefore exists for novel forms of analgesia, wider spread use of available analgesic agents which overcome some limitations associated with several treatment options, and the development of protocols for pain management which include patient assessment of pain.Funding: Mundipharma International Ltd.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.