ArticleJournal of animal science2018
Genetic, maternal, and heterosis effects on voluntary water consumption in mice.
Article in Journal of animal science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Genetic basis of voluntary water consumption in two divergently selected strains of inbred mice.Veterinary medicine and science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In standard laboratory conditions, inbred mouse strains with normal kidney function show a 4-fold range of daily water consumption. This study uses two strains of inbred mice identified as high and low consumers, their reciprocal F1 crosses, and inter se bred F2s. Daily consumption data were collected on 607 animals for 4 d during the 4th, 5th, and 6th wk using custom water bottles. Animals were weighed at the beginning of the 4th, 5th, 6th, and 7th wk. Consumption data were corrected for metabolic BW (Bwt0.67) prior to analysis, so units of water consumption are expressed in mL consumed per gram of Bwt0.67 per day. Variables BW and water consumption were fitted to a mixed model including the effects of sex, strain, and their interaction with sire within strain fitted as a random effect. Contrasts were designed to test the direct genetic, maternal genetic, individual heterosis, and maternal heterosis effects. An interaction (P < 0.0001) was observed between sex and strain so all analyses were conducted separately for each sex. C57Brown/CDJ animals (Brown) consumed more water than C57Black/10J animals (Black) (P < 0.0001). A maternal effect (P = 0.036, P = 0.029) was observed in males at the 4th and 5th wk as F1 animals with a Black dam (F1Black) consumed less than F1 animals with a Brown dam (F1Brown) males. No significant heterosis effect was observed for water consumption. For weight analysis, Black animals were significantly larger than Brown animals at 28 d (males P = 0.004, females P = 0.026), but no difference was observed the remainder of the trial. Further, F1Brown females were significantly smaller than F1Black females at 28 d (P < 0.0001) and F1Brown males tended to be smaller than F1Black males (P = 0.078). Animals from the reciprocal F1 crosses showed an increase in birth weight (P < 0.0001) over pure strains. These strains form the foundation stock of an experiment designed to isolate genes influencing water consumption by reciprocal backcrossing and selection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.