ArticleInvestigative ophthalmology & visual science2018
Peripapillary Retinoschisis in Glaucoma: Association With Progression and OCT Signs of Müller Cell Involvement.
Article in Investigative ophthalmology & visual science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Optic nerve head abnormalities in primary open-angle glaucoma and their associations with axial length.Japanese journal of ophthalmology · 2026Article
- Clinical features of high myopia with optic nerve head prelaminar schisis: Wuhan high myopia study.Eye (London, England) · 2025Article
- Histological Assessment of Foveal Mechanical Instability and Potential Implications for Macular Diseases.Investigative ophthalmology & visual science · 2025Article
- Severe macular complications in glaucoma: high-resolution multimodal imaging characteristics and review of the literature.BMC ophthalmology · 2023Review
- Glaucomatous optic nerve damage in the contralateral eye of a patient with peripapillary retinoschisis: a case report.BMC ophthalmology · 2023Article
- Astrocyte Immune Functions and Glaucoma.International journal of molecular sciences · 2023Review
- Optic nerve cavitations in glaucoma suspect and glaucoma patients.American journal of ophthalmology case reports · 2022Article
- Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets.Progress in retinal and eye research · 2022Review
- Hypodense regions in the peripapillary region increased the risk of macular retinoschisis detected by optical coherence tomography.Frontiers in medicine · 2022Article
- Peripapillary and macular retinoschisis - A vision-threatening sequelae of advanced glaucomatous cupping.Indian journal of ophthalmology · 2021Article
- Disc hemorrhage following peripapillary retinoschisis in glaucoma: a case report.BMC ophthalmology · 2021Article
- The Progression of Peripapillary Retinoschisis May Indicate the Progression of Glaucoma.Investigative ophthalmology & visual science · 2021Article
- Factors Determining the Morphology of Peripapillary Retinoschisis.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Foveal regeneration after resolution of cystoid macular edema without and with internal limiting membrane detachment: presumed role of glial cells for foveal structure stabilization.International journal of ophthalmology · 2021Article
- Vitrectomy with peripapillary internal limiting membrane peeling for macular retinoschisis associated with normal-tension glaucoma.American journal of ophthalmology case reports · 2020Article
- A proposed mechanism influencing structural patterns in X-linked retinoschisis and stellate nonhereditary idiopathic foveomacular retinoschisis.Eye (London, England) · 2019Article
- Clinicians' Use of Quantitative Information When Assessing the Rate of Structural Progression in Glaucoma.Ophthalmology. GlaucomaArticle
- Peripapillary Retinoschisis as a Manifestation of Ocular Hypotony.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Purpose: To examine demographic and clinical factors associated with glaucomatous peripapillary retinoschisis (PPRS) and assess its association with glaucoma progression. Methods: Using a case control study design and longitudinal data from a cohort of 166 subjects with a diagnosis of glaucoma or glaucoma suspect, we compared functional, structural, clinical, and demographic characteristics between PPRS cases and controls. Results: The frequency of PPRS was 6.0% (12 eyes from 10/166 subjects) with two eyes having PPRS in different sectors for a total of 15 retinoschisis events. There were no significant differences (P > 0.05) in age, sex, visual acuity, central corneal thickness, intraocular pressure, or presence of vitreous adhesion between PPRS and controls. However, eyes with PPRS tended to have a higher cup-to-disc ratio (P = 0.06), thinner RNFL (P = 0.02), and worse visual field mean deviation (MD, P = 0.06) than controls. The rate of RNFL thinning was faster in PPRS (average: -2.8%/year; range: -7.4% to 0.0%/year) than controls (-1.3%/year; range: -4.4% to 0.6%/year; P = 0.021). The rate of visual field MD change was faster in PPRS (-0.49 dB/year; range: -2.0 to 0.9 dB/year) than controls (-0.06 dB/year; range: -0.8 to 0.3 dB/year; P = 0.030). OCT scans showed hyperreflective structures spanning the PPRS whose morphology and spacing (50 ± 7 μm) are consistent with Müller glia, causing signal attenuation casting "shadows" onto distal retina. Conclusions: This is the first report showing that glaucomatous PPRS is associated with a faster overall rate of RNFL thinning and visual field deterioration and to specifically identify OCT signs of Müller cell involvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.