Evidence map›Paper›PMID 29860453›Full record

Trial reportInvestigative ophthalmology & visual science2018

The Effect of Longer-Term and Exclusive Breastfeeding Promotion on Visual Outcome in Adolescence.

Christopher G Owen, Emily Oken, Alicja R Rudnicka, Rita Patel, Jennifer Thompson, Sheryl L Rifas-Shiman, Konstatin Vilchuck, Natalia Bogdanovich, Mikhail Hameza, Michael S Kramer and 1 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Investigative ophthalmology & visual science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01561612 (Breastfeeding Promotion RCT and Child Metabolic Syndrome), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01561612 nacompletednot on this map

Breastfeeding Promotion RCT and Child Metabolic Syndrome

TypeinterventionalSponsorHarvard Pilgrim Health CareRan1996Enrolled17,046ConditionsEffect of Breastfeeding on Maternal and Child Health OutcomesArmsBreastfeeding promotion and support
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Christopher G OwenPopulation Health Research Institute, St. George's, University of London, Cranmer Terrace, London, United Kingdom.
Emily OkenDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States.
Alicja R RudnickaPopulation Health Research Institute, St. George's, University of London, Cranmer Terrace, London, United Kingdom.
Rita PatelBristol Medical School: Population Health Sciences, University of Bristol, Bristol, United Kingdom.
Jennifer ThompsonDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States.
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States.
Konstatin VilchuckNational Research and Applied Medicine Mother and Child Centre, Minsk, Republic of Belarus.
Natalia BogdanovichNational Research and Applied Medicine Mother and Child Centre, Minsk, Republic of Belarus.
Mikhail HamezaNational Research and Applied Medicine Mother and Child Centre, Minsk, Republic of Belarus.
Michael S KramerDepartments of Pediatrics and of Epidemiology, Biostatistics and Occupational Health, McGill University Faculty of Medicine, Montreal, Canada.
Richard M MartinBristol Medical School: Population Health Sciences, University of Bristol, Bristol, United Kingdom.
Harvard University · USSt George's, University of London · GBHarvard Pilgrim Health Care · USMcGill University · CANational Institute for Health Research · GBUniversity of Bristol · GB

Funding

Breastfeeding RCT: Adolescent Neurocognitive and Respiratory FunctionR01HD050758 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI MARTIN, RICHARD MICHAEL, OKEN, EMILY · 2007 to 2014
$3.0M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
CIHR MOP-53155Medical Research CouncilNICHD NIH HHS K24 HD069408NICHD NIH HHS R01 HD050758
6 · The paper itself

Abstract

Purpose: Breastfeeding may influence early visual development. We examined whether an intervention to promote increased duration and exclusivity of breastfeeding improves visual outcomes at 16 years of age. Methods: Follow-up of a cluster-randomized trial in 31 Belarusian maternity hospitals/polyclinics randomized to receive a breastfeeding promotion intervention, or usual care, where 46% vs. 3% were exclusively breastfed at 3 months respectively. Low vision in either eye was defined as unaided logMAR vision of ≥0.3 or worse (equivalent to Snellen 20/40) and was used as the primary outcome. Open-field autorefraction in a subset (n = 963) suggested that 84% of those with low vision were myopic. Primary analysis was based on modified intention-to-treat, accounting for clustering within hospitals/clinics. Observational analyses also examined the effect of breastfeeding duration and exclusivity, as well as other sociodemographic and environmental determinants of low vision. Results: A total of 13,392 of 17,046 (79%) participants were followed up at 16 years. Low vision prevalence was 19.6% (95% confidence interval [CI]: 17.5, 22.0%) in the experimental group versus 21.6% (19.5, 23.8%) in the control group. Cluster-adjusted odds ratio (OR) of low vision associated with the intervention was 0.92 (95% CI: 0.73, 1.16); 0.88 (95% CI: 0.74, 1.05) after adjustment for parental and early life factors. In observational analyses, breastfeeding duration and exclusivity had no significant effect on low vision. However, maternal age at birth (OR: 1.13, 95% CI: 1.07, 1.14/5-year increase) and urban versus rural residence were associated with increased risk of low vision. Lower parental education, number of older siblings was associated with a lower risk of low vision; boys had lower risk compared with girls (0.64, 95% CI: 0.59,0.70). Conclusions: Exclusive breastfeeding promotion had no significant effect on visual outcomes in this study, but other environmental factors showed strong associations. (ClinicalTrials.gov number, NCT01561612.).

Indexed as

Breast FeedingHealth PromotionAdolescentAdolescent HealthAdultFemaleFollow-Up StudiesHumansMaleMaternal AgeRepublic of BelarusRural PopulationTime FactorsUrban PopulationVision, LowVisual Acuity

Identifiers

PMID29860453
PMCPMC5983062
OpenAlexW2805897511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.