Evidence map›Paper›PMID 29860365›Full record

ArticleAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2018

Is Resolution of Chronic Pain Associated With Changes in Blood Pressure-related Hypoalgesia?

Pablo de la Coba, Stephen Bruehl, Judy Garber, Craig A Smith, Lynn S Walker

Open access · bronzeAbstract read
In one paragraph

Article in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Circadian Variation of Blood Pressure in Patients with Chronic Musculoskeletal Pain: A Cross-Sectional Study.International journal of environmental research and public health · 2022
    Observational
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Pablo de la CobaDepartment of Psychology, University of Jaén, Jaén, Spain.
Stephen BruehlDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Judy GarberDepartment of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
Craig A SmithDepartment of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
Lynn S WalkerDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University · USVanderbilt University Medical Center · USUniversidad de Jaén · ES

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
THREE-TIERED PREVENTION MODEL TO BETTER SERVE ALL STUDENP30HD015052 · NICHD · VANDERBILT UNIVERSITY · PI HARRELL, FRANK E. · 1985 to 2014
$18.6M
ILLNESS BEHAVIOR AND SOMATIZATION IN CHILDRENR01HD023264 · NICHD · VANDERBILT UNIVERSITY · PI WALKER, LYNN D. · 1987 to 2011
$3.9M
Predicting Treatment Response in Pediatric Functional Abdominal PainR01HD076983 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALKER, LYNN D. · 2014 to 2018
$2.9M
National Center for Research Resources UL1 RR024975NICHD NIH HHS P30 HD015052NICHD NIH HHS R01 HD023264NICHD NIH HHS R01 HD076983NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

Background: In healthy individuals, elevated resting blood pressure (BP) is associated with reduced pain responsiveness and lower temporal summation. Prior work indicates that this BP-related hypoalgesia is reduced in individuals with chronic pain. Purpose: This study evaluated whether resolution of chronic pain was associated with greater BP-related hypoalgesia compared to nonresolution. Methods: From a prospective sample of adolescents and young adults diagnosed with chronic functional abdominal pain an average of 9 years earlier, 99 individuals in whom the condition had resolved and 51 individuals with ongoing abdominal pain were studied. Resting systolic BP was assessed, followed by evaluation of thermal pain threshold and tolerance, and assessment of temporal summation to thermal pain stimuli. Results: Higher resting systolic BP was significantly associated with higher pain threshold and tolerance, and lower temporal summation only in the group with resolved functional abdominal pain (p < .05). Hierarchical regressions revealed that interactions between BP and resolution of chronic pain were significant only for pain tolerance (p < .05). Analyses by sex indicated that interactions between BP and resolution status were significant for the temporal summation outcome in males but not in females. Conclusions: Results suggest that BP-related hypoalgesic mechanisms may be more effective in individuals in whom chronic pain has resolved compared to those with ongoing chronic pain. Findings hint at sex differences in the extent to which resolution of chronic pain is associated with BP-related hypoalgesia. Whether greater BP-related hypoalgesia is a consequence of, or alternatively a contributor to, resolution of chronic pain warrants further investigation.

Indexed as

Blood PressureAbdominal PainAdolescentChildChronic PainFemaleHumansMalePain MeasurementPain PerceptionPain ThresholdProspective StudiesSex FactorsYoung Adult

Identifiers

PMID29860365
PMCPMC6361258
OpenAlexW2792444096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.