ArticleSchizophrenia bulletin2019
Childhood Trauma Associated White Matter Abnormalities in First-Episode Schizophrenia.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Brain structure and function in adult survivors of developmental trauma with psychosis: A systematic review.Psychological medicine · 2025Pooled it
- Functional brain connectivity in clinical high-risk youth from the Kenya psychosis-risk outcomes study (KePROS): functional network comparative area and topography analysis (FUNCATA).NeuroImage. Clinical · 2026Article
- [White matter microstructural disturbance and its relationship with cognitive function in schizophrenia with comorbidity of metabolic syndrome].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Analysis of Normalizers and Neurodevelopment-Related microRNAs in the Prefrontal Cortex and in the Sperm of SHR Rats.International journal of molecular sciences · 2025Article
- Orbitofrontal functional network: the mediating role between violence and childhood trauma in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- The relationship between lifetime trauma exposure and psychosis in a multi-country case-control study in Africa.SSM. Mental health · 2025Article
- Brain White Matter Alterations in Young Adults with Childhood Emotional Neglect Experience.Behavioral sciences (Basel, Switzerland) · 2025Article
- Cerebrolysin Induces Dendritic Tree Plastic Changes and BDNF Increase in the Amygdala of Male Rats with Maternal Deprivation.Neurochemical research · 2025Article
- Advances in MRI Research for First-Episode Schizophrenia: A Selective Review and NSFC-Funded Analysis.Schizophrenia bulletin · 2025Review
- Correlates of adverse childhood experiences among admitted patients with schizophrenia in a referral psychiatric hospital in Botswana.The International journal of social psychiatry · 2025Article
- The effect of childhood trauma on moral cognition in patients with schizophrenia.Frontiers in psychiatry · 2024Article
- Threat Responses in Schizophrenia: A Negative Valence Systems Framework.Current psychiatry reports · 2024Review
- Independent effects of early life adversity on social cognitive function in patients with schizophrenia.Frontiers in psychiatry · 2024Article
- Article
- A culturally adapted brief intervention for post-traumatic stress disorder in people with severe mental illness in Botswana: protocol for a randomised feasibility trial.Pilot and feasibility studies · 2021Article
- The relationship between childhood trauma and schizophrenia in the Genomics of Schizophrenia in the Xhosa people (SAX) study in South Africa.Psychological medicine · 2020Article
- Childhood Trauma in Persons With Schizophrenia and a History of Interpersonal Violence.Frontiers in psychiatry · 2020Article
- Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is associated with brain connection irregularities within and between brain regions. Childhood trauma increases the risk of schizophrenia suggesting that the relationships between childhood trauma and brain connectivity requires further investigation. Here, we examine the relationship between childhood trauma (as measured by the Childhood Trauma Questionnaire) and fractional anisotropy (FA) in 54 minimally treated first-episode schizophrenia (FES) patients and 51 community matched controls. Patients who experienced high levels of trauma had significantly lower FA in the inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus (SLF), and inferior fronto-occipital fasciculus (IFOF) compared with controls who experienced high levels of childhood trauma. A history of childhood sexual abuse in patients was associated with lower FA in the IFOF, ILF, SLF, and forceps major compared with patients without a history of sexual abuse. However, patients who had experienced childhood emotional neglect had higher FA in the right SLF compared to patients with low levels of emotional neglect. Our findings highlight altered cortico-limbic circuitry in FES patients compared with controls and differential effects of childhood emotional neglect and sexual abuse on white matter in patients. Although stress-related white matter (WM) pathways appear to be involved in both schizophrenia and otherwise healthy controls previously exposed to childhood trauma, the pattern of disruption of WM integrity in FES patients appears to be distinct.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.