Evidence map›Paper›PMID 29860290›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018

Are We on Our Way to Achieving the 2020 Goals for Schistosomiasis Morbidity Control Using Current World Health Organization Guidelines?

Jaspreet Toor, Ramzi Alsallaq, James E Truscott, Hugo C Turner, Marleen Werkman, David Gurarie, Charles H King, Roy M Anderson

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In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. SCORE Operational Research on Moving toward Interruption of Schistosomiasis Transmission.The American journal of tropical medicine and hygiene · 2020
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  20. Molecular characterization of schistosome cercariae and theirCurrent research in parasitology & vector-borne diseases · 2023
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jaspreet ToorLondon Centre for Neglected Tropical Disease Research, Imperial College London, United Kingdom.
Ramzi AlsallaqCenter for Global Health and Diseases and Department of Mathematics, Case Western Reserve University, Cleveland, Ohio.
James E TruscottLondon Centre for Neglected Tropical Disease Research, Imperial College London, United Kingdom.
Hugo C TurnerOxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.
Marleen WerkmanLondon Centre for Neglected Tropical Disease Research, Imperial College London, United Kingdom.
David GurarieCenter for Global Health and Diseases and Department of Mathematics, Case Western Reserve University, Cleveland, Ohio.
Charles H KingCenter for Global Health and Diseases and Department of Mathematics, Case Western Reserve University, Cleveland, Ohio.
Roy M AndersonLondon Centre for Neglected Tropical Disease Research, Imperial College London, United Kingdom.

Funding

Medical Research Council MR/R015600/1
6 · The paper itself

Abstract

Background: Schistosomiasis remains an endemic parasitic disease affecting millions of people around the world. The World Health Organization (WHO) has set goals of controlling morbidity to be reached by 2020, along with elimination as a public health problem in certain regions by 2025. Mathematical models of parasite transmission and treatment impact have been developed to assist in controlling the morbidity caused by schistosomiasis. These models can inform and guide implementation policy for mass drug administration programs, and help design monitoring and evaluation activities. Methods: We use these models to predict whether the guidelines set by the WHO are on track for achieving their 2020 goal for the control of morbidity, specifically for Schistosoma mansoni. We examine whether programmatic adaptations; namely increases in treatment coverage and/or expansion to adult inclusion in treatment, will improve the likelihood of reaching the WHO goals. Results: We find that in low-prevalence settings, the goals are likely to be attainable under current WHO guidelines, but in moderate to high-prevalence settings, the goals are less likely to be achieved unless treatment coverage is increased and expanded to at least 85% for school-aged children and 40% for adults. Conclusions: To improve the likelihood of reaching the WHO goals, programmatic adaptations are required, particularly for moderate- to high-prevalence settings. Furthermore, improvements in adherence to treatment, potential development of candidate vaccines, and enhanced snail control and WASH (water, sanitation, and hygiene) measures will all assist in achieving the goals.

Indexed as

Models, TheoreticalPractice Guidelines as TopicPublic HealthAnimalsDisease EradicationEndemic DiseasesGoalsHumansHygieneMass Drug AdministrationMorbidityPrevalenceSanitationSchistosomiasisWorld Health Organization

Identifiers

PMID29860290
PMCPMC5982704

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.