ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018
Investigating the Effectiveness of Current and Modified World Health Organization Guidelines for the Control of Soil-Transmitted Helminth Infections.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A systematic review of mathematical models for soil-transmitted helminthiasis control strategies.PLoS neglected tropical diseases · 2026Pooled it
- Global prevalence and public health impact of intestinal parasitic infections in children under five: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- A historical and systematic overview ofParasitology · 2021Pooled it
- In silico design of a T-cell epitope vaccine candidate for parasitic helminth infection.PLoS pathogens · 2020Pooled it
- Pooled it
- Policy stakeholder perspectives on barriers and facilitators to launching a community-wide mass drug administration program for soil-transmitted helminths.Global health research and policy · 2022Trial
- Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial.The Lancet. Infectious diseases · 2021Trial
- Intestinal parasitic infection among household contacts of primary cases, a comparative cross-sectional study.PloS one · 2019Trial
- The impact of the termination of Lymphatic Filariasis mass drug administration on Soil-transmitted Helminth prevalence in school children in Malawi.PLoS neglected tropical diseases · 2026Article
- Burden of Intestinal Parasitic Infections and the Intensity of Helminth Infection Among Primary School Children in Sidama, Ethiopia: A Zero-Inflated Negative Binomial Analysis.Journal of parasitology research · 2026Article
- Anthelmintic Potential and In Silico Studies of Ricinoleic Acid from the Seed Oil ofInternational journal of molecular sciences · 2025Article
- Assessing the Burden of Neglected Tropical Diseases in Low-Income Communities: Challenges and Solutions.Viruses · 2024Review
- A scoping review of transmission models for soil-transmitted helminth infections to underpin the development of a transmission model forParasitology · 2024Article
- Metabolomics (Non-Targeted) of Induced Type 2 Diabetic Sprague Dawley Rats Comorbid with a Tissue-Dwelling Nematode Parasite.International journal of molecular sciences · 2023Article
- Intestinal parasitic infections among children aged 12-59 months in Nyamasheke District, Rwanda.Parasites, hosts and diseases · 2023Article
- Understanding factors responsible for the slow decline of soil-transmitted helminthiasis following seven rounds of annual mass drug administration (2012-2018) among school children in endemic counties of Kenya: A mixed method study.PLoS neglected tropical diseases · 2023Article
- The prevalence of intestinal parasites, undernutrition and their associated risk factors among school-age children in Sekota Town, Northeast Ethiopia: A community-based cross-sectional study.Health science reports · 2023Article
- Optimal control analysis of a transmission interruption model for the soil-transmitted helminth infections in Kenya.Current research in parasitology & vector-borne diseases · 2023Article
- Modeling the effectiveness of One Health interventions against the zoonotic hookwormFrontiers in medicine · 2023Article
- Evaluating and mitigating the potential indirect effect of COVID-19 on control programmes for seven neglected tropical diseases: a modelling study.The Lancet. Global health · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Background: Considerable efforts have been made to better understand the effectiveness of large-scale preventive chemotherapy therapy for the control of morbidity caused by infection with soil-transmitted helminths (STHs): Ascaris lumbricoides, Trichuris trichiura, and the 2 hookworm species, Necator americanus and Ancylostoma duodenale. Current World Health Organization (WHO) guidelines for STH control include mass drug administration (MDA) programs based on prevalence measurements, aiming at reducing morbidity in pre-school-aged children (pre-SAC) and school-aged children (SAC) by lowering the prevalence of moderate- to heavy-intensity infections to <1%. Methods: We project the likely impact of following the current WHO guidelines and assess whether the WHO morbidity goals will be achieved across a range of transmission settings. We also investigate modifications that could be made to the current WHO treatment guidelines, and project their potential impacts in achieving morbidity and transmission control. Results: While the standard guidelines are sufficient at low transmission levels, community-wide treatment (ie, involving pre-SAC, SAC, and adults) is essential if WHO morbidity goals are to be met in moderate- to high-transmission settings. Moreover, removing the recommendation of decreasing the treatment frequency at midline (5-6 years after the start of MDA) further improves the likelihood of achieving morbidity control in SAC. Conclusions: We meld analyses based on 2 mathematical models of parasite transmission and control by MDA for the dominant STH species, to generate a unified treatment approach applicable across all settings, regardless of which STH infection is most common. We recommend clearly defined changes to the current WHO guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.