ReviewSeminars in cell & developmental biology2019
Adjustable viscoelasticity allows for efficient collective cell migration.
Review in Seminars in cell & developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Concurrent jamming and mesenchymal-to-epithelial transitions during airway basal stem cell differentiation.iScience · 2026Article
- Anisotropy and shear stress accumulation during collective migration of epithelial cells.European biophysics journal : EBJ · 2026Review
- Macrophages Mediate Mesoscale Brain Mechanical Homeostasis.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Review
- Viscoelastic differences between isolated and live MCF7 cancer cell nuclei resolved with AFM microrheology.Journal of the Royal Society, Interface · 2025Article
- Targeted elimination of mesenchymal-like cancer cells through cyclic stretch activation of Piezo1 channels: the physical aspects.Biophysical reviews · 2025Review
- Entropy Production in Epithelial Monolayers Due to Collective Cell Migration.Entropy (Basel, Switzerland) · 2025Review
- The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migratory plasticity.npj biological physics and mechanics · 2025Review
- The role of extracellular matrix viscoelasticity in development and disease.npj biological physics and mechanics · 2025Review
- Article
- Multi-Zone Visco-Node-Pore Sensing: A Microfluidic Platform for Multi-Frequency Viscoelastic Phenotyping of Single Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Physical aspects of epithelial cell-cell interactions: hidden system complexities.European biophysics journal : EBJ · 2024Review
- Epithelial cell-cell interactions in an overcrowded environment: jamming or live cell extrusion.Journal of biological engineering · 2024Review
- Lightsheet microscopy integrates single-cell optical visco-elastography and fluorescence cytometry of 3D live tissues.bioRxiv : the preprint server for biology · 2024Article
- Role of viscoelasticity in the appearance of low-Reynolds turbulence: considerations for modelling.Journal of biological engineering · 2024Review
- Mechanobiology in cellular, molecular, and tissue adaptation.Mechanobiology in medicine · 2023Article
- Generative models of morphogenesis in developmental biology.Seminars in cell & developmental biology · 2023Review
- Response of cells and tissues to shear stress.Journal of cell science · 2023Review
- Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways.Development (Cambridge, England) · 2023Article
- Lose the stress: Viscoelastic materials for cell engineering.Acta biomaterialia · 2023Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Cell migration is essential for a wide range of biological processes such as embryo morphogenesis, wound healing, regeneration, and also in pathological conditions, such as cancer. In such contexts, cells are required to migrate as individual entities or as highly coordinated collectives, both of which requiring cells to respond to molecular and mechanical cues from their environment. However, whilst the function of chemical cues in cell migration is comparatively well understood, the role of tissue mechanics on cell migration is just starting to be studied. Recent studies suggest that the dynamic tuning of the viscoelasticity within a migratory cluster of cells, and the adequate elastic properties of its surrounding tissues, are essential to allow efficient collective cell migration in vivo. In this review we focus on the role of viscoelasticity in the control of collective cell migration in various cellular systems, mentioning briefly some aspects of single cell migration. We aim to provide details on how viscoelasticity of collectively migrating groups of cells and their surroundings is adjusted to ensure correct morphogenesis, wound healing, and metastasis. Finally, we attempt to show that environmental viscoelasticity triggers molecular changes within migrating clusters and that these new molecular setups modify clusters' viscoelasticity, ultimately allowing them to migrate across the challenging geometries of their microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.