Evidence map›Paper›PMID 29859955›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2018

Remote control of movement disorders using a photoactive adenosine A

Jaume Taura, Ernest G Nolen, Gisela Cabré, Jordi Hernando, Lucia Squarcialupi, Marc López-Cano, Kenneth A Jacobson, Víctor Fernández-Dueñas, Francisco Ciruela

Open access · bronzeAbstract read
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  8. Current Status and Future Strategies for Advancing Functional Circuit MappingThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  9. Review
  10. Article
  11. Article
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  13. Article
  14. Article
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  16. Article
  17. Optical control of purinergic signaling.Purinergic signalling · 2021
    Review
  18. Article
  19. Optical control of adenosine APharmacological research · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jaume TauraUnitat de Farmacologia, Departament Patologia i Terapéutica Experimental, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Institut de Neurociències, Universitat de Barcelona, Spain.
Ernest G NolenColgate University, Hamilton, USA.
Gisela CabréDepartament de Química, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Jordi HernandoDepartament de Química, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Lucia SquarcialupiMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA.
Marc López-CanoUnitat de Farmacologia, Departament Patologia i Terapéutica Experimental, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Institut de Neurociències, Universitat de Barcelona, Spain.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA. Electronic address: kennethj@niddk.nih.gov.
Víctor Fernández-DueñasUnitat de Farmacologia, Departament Patologia i Terapéutica Experimental, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Institut de Neurociències, Universitat de Barcelona, Spain.
Francisco CiruelaUnitat de Farmacologia, Departament Patologia i Terapéutica Experimental, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Institut de Neurociències, Universitat de Barcelona, Spain. Electronic address: ciruela@ub.edu.
Institut d'Investigació Biomédica de Bellvitge · ESNational Institutes of Health · USUniversitat Autònoma de Barcelona · ESColgate University · US

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Intramural NIH HHS ZIA DK031117
6 · The paper itself

Abstract

G protein-coupled adenosine receptors are promising therapeutic targets for a wide range of neuropathological conditions, including Parkinson's disease (PD). However, the ubiquity of adenosine receptors and the ultimate lack of selectivity of certain adenosine-based drugs have frequently diminished their therapeutic use. Photopharmacology is a novel approach that allows the spatiotemporal control of receptor function, thus circumventing some of these limitations. Here, we aimed to develop a light-sensitive caged adenosine A

Indexed as

LightAdenosine A2 Receptor AntagonistsAnimalsBrainDisease Models, AnimalHEK293 CellsHumansLocomotionMiceMovement DisordersOptical FibersReceptor, Adenosine A2AAdenosine A2 Receptor AntagonistsReceptor, Adenosine A2AAdenosine A(2A) receptorCatalepsyLocomotor activityMovement disorderParkinson's diseasePhotopharmacologySCH442416Tremor

Identifiers

PMID29859955
PMCPMC6098950
OpenAlexW2805347964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.