ArticleInternational journal of radiation oncology, biology, physics2018
In Vivo Validation of Elekta's Clarity Autoscan for Ultrasound-based Intrafraction Motion Estimation of the Prostate During Radiation Therapy.
Article in International journal of radiation oncology, biology, physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02388308 (Evaluation of Clarity Ultrasound Guidance for Prostate Therapy), which is not on this map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Clarity Ultrasound Guidance for Prostate Therapy
Who cites it
21 citing papers in PubMed.
- Real-time motion tracking of a gold implant in water by Cherenkov lights.Journal of applied clinical medical physics · 2026Article
- The Kilovoltage Intrafraction Monitoring Real-Time Prostate Cancer Image Guided Radiation Therapy Technology Journey: From Clinical Trials to Your Clinic.International journal of radiation oncology, biology, physics · 2026Article
- Multiple radiations and its effect on biological system - a review onAnnals of medicine · 2025Review
- Advancing the Collaboration Between Imaging and Radiation Oncology.Seminars in radiation oncology · 2024Review
- Treatment outcome of localized prostate cancer using transperineal ultrasound image-guided radiotherapy.Radiation oncology (London, England) · 2024Article
- Prostate intra-fraction motion recorded by transperineal ultrasound.Scientific data · 2024Article
- Biomedical advances and future prospects of high-precision three-dimensional radiotherapy and four-dimensional radiotherapy.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Transperineal ultrasound is a good alternative for intra-fraction motion monitoring for prostate stereotactic body radiotherapy.Journal of applied clinical medical physics · 2023Article
- Assessment of intrafraction motion and its dosimetric impact on prostate radiotherapy using an in-house developed position monitoring system.Frontiers in oncology · 2023Article
- Impact of transperineal ultrasound on perineal skin dose in prostate radiation therapy.Technical innovations & patient support in radiation oncology · 2022Article
- Injection of hydrogel spacer increased maximal intrafractional prostate motion in anterior and superior directions during volumetric modulated arc therapy-stereotactic body radiation therapy for prostate cancer.Radiation oncology (London, England) · 2022Article
- A phantom-based analysis for tracking intra-fraction pancreatic tumor motion by ultrasound imaging during radiation therapy.Frontiers in oncology · 2022Article
- The Potential of Photoacoustic Imaging in Radiation Oncology.Frontiers in oncology · 2022Article
- Early toxicities of ultrahypofractionated stereotactic body radiotherapy for intermediate risk localized prostate cancer using cone-beam computed tomography and real-time three-dimensional transperineal ultrasound monitoring.Radiation oncology journal · 2021Article
- Technical considerations for positioning and placement of a transperineal ultrasound probe during prostate radiotherapy.Journal of medical radiation sciences · 2021Article
- Factors affecting accuracy and precision in ultrasound guided radiotherapy.Physics and imaging in radiation oncology · 2021Article
- Improving 3D ultrasound prostate localisation in radiotherapy through increased automation of interfraction matching.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2020Article
- A study of the clinical, treatment planning and dosimetric feasibility of dose painting in external beam radiotherapy of prostate cancer.Physics and imaging in radiation oncology · 2020Article
- Real-time intrafraction motion monitoring in external beam radiotherapy.Physics in medicine and biology · 2019Review
- 3D-US and CBCT Dual-guided Radiotherapy for Postoperative Uterine Malignancy: A Primary Workflow Set-up.Technology in cancer research & treatmentArticle
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Authors and funding
8 authors.
Funding
Abstract
purposeOur purpose was to perform an in vivo validation of ultrasound imaging for intrafraction motion estimation using the Elekta Clarity Autoscan system during prostate radiation therapy. The study was conducted as part of the Clarity-Pro trial (NCT02388308). METHODS AND MATERIALS: Initial locations of intraprostatic fiducial markers were identified from cone beam computed tomography scans. Marker positions were translated according to Clarity intrafraction 3-dimensional prostate motion estimates. The updated locations were projected onto the 2-dimensional electronic portal imager plane. These Clarity-based estimates were compared with the actual portal-imaged 2-dimensional marker positions. Images from 16 patients encompassing 80 fractions were analyzed. To investigate the influence of intraprostatic markers and image quality on ultrasound motion estimation, 3 observers rated image quality, and the marker visibility on ultrasound images was assessed.
resultsThe median difference between Clarity-defined intrafraction marker locations and portal-imaged marker locations was 0.6 mm (with 95% limit of agreement at 2.5 mm). Markers were identified on ultrasound in only 3 of a possible 240 instances. No linear relationship between image quality and Clarity motion estimation confidence was identified. The difference between Clarity-based motion estimates and electronic portal-imaged marker location was also independent of image quality. Clarity estimation confidence was degraded in a single fraction owing to poor probe placement.
conclusionsThe accuracy of Clarity intrafraction prostate motion estimation is comparable with that of other motion-monitoring systems in radiation therapy. The effect of fiducial markers in the study was deemed negligible as they were rarely visible on ultrasound images compared with intrinsic anatomic features. Clarity motion estimation confidence was robust to variations in image quality and the number of ultrasound-imaged anatomic features; however, it was degraded as a result of poor probe placement.
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