Evidence map›Paper›PMID 29859760›Full record

ArticleExperimental eye research2018

Prion protein modulates iron transport in the anterior segment: Implications for ocular iron homeostasis and prion transmission.

Ajay Ashok, Shilpita Karmakar, Rajeev Chandel, Ranjana Ravikumar, Stuti Dalal, Qingzhong Kong, Neena Singh

Open access · hybridAbstract read
In one paragraph

Article in Experimental eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Prions and prion diseases: Insights from the eye.Experimental eye research · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ajay AshokDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Shilpita KarmakarDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Rajeev ChandelDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Ranjana RavikumarDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Stuti DalalDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Qingzhong KongDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Neena SinghDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA. Electronic address: neena.singh@case.edu.
Case Western Reserve University · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
The iron modulatory function of prion protein and prion disordersR01NS092145 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SINGH, NEENA · 2015 to 2019
$2.4M
Assessing the Transmissibility of CWD to HumansR01NS052319 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2006 to 2010
$1.7M
Cervid to human prion transmissionR01NS088604 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2015 to 2018
$1.4M
Local hepcidin in the anterior segment: Physiological and pathological implicationsR21EY032694 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SINGH, NEENA · 2022 to 2023
$443k
NEI NIH HHS P30 EY011373NEI NIH HHS R21 EY032694NINDS NIH HHS R01 NS052319NINDS NIH HHS R01 NS088604NINDS NIH HHS R01 NS092145
6 · The paper itself

Abstract

Iron is an essential biometal in the aqueous humor, the principal source of nutrients for the avascular cornea and the lens. Here, we explored whether the ciliary body (CB), the source of aqueous humor, transports iron, and if the prion protein (PrP

Indexed as

AnimalsAnterior Eye SegmentBiological TransportBlotting, WesternCation Transport ProteinsCattleCeruloplasminCiliary BodyDisease Models, AnimalElectrophoresis, Polyacrylamide GelEpithelial CellsFemaleFerritinsFerroportinFluorescent Antibody Technique, IndirectHomeostasisCation Transport ProteinsCeruloplasminCp protein, mouseFerritinsFerroportinIron-Binding ProteinsPrPC ProteinsReceptors, TransferrinTransferrinAqueous humorCiliary epitheliumCorneaIronPrion proteinβ-cleavage

Identifiers

PMID29859760
PMCPMC6167182
OpenAlexW2806462251

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.