ArticleJournal of chromatography. A2018
A new method to prepare and redefine black tea thearubigins.
Article in Journal of chromatography. A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 33 citations in OpenAlex.
- GC-Ms, UHPLC-MS/MSChemistry & biodiversity · 2026Article
- Compositional and biochemical activity evaluation of highly polymerized tea pigments in black tea based on natural deep eutectic solvent extraction.Food chemistry: X · 2025Article
- Exploring the potential of underrated yet versatile cropHeliyon · 2025Article
- [Identification of chemical components of large-leaf yellow tea by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry].Se pu = Chinese journal of chromatography · 2024Article
- Recent Advances in Analytical Methods for Determination of Polyphenols in Tea: A Comprehensive Review.Foods (Basel, Switzerland) · 2022Review
- Gut Microbiota as a Novel Tool to Dissect the Complex Structures of Black Tea Polymers.Journal of agricultural and food chemistry · 2022Article
- A Study on Tissue-Specific Metabolite Variations inMolecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Thearubigins (TRs) are the major components of black tea, which are formed during the fermentation reactions. Although anti-inflammatory and anti-cancer activities of TRs have been reported, the prepared TRs according to the literature methods still contain many floating peaks. It is puzzling whether the observed activities are from TRs or these floating peaks. Thus, it is urgent to develop a method to prepare pure TRs and redefine them. In the present study, we developed a new method, the combination of caffeine precipitation and Sephadex LH-20 column chromatography, to prepare pure TRs. The floating peaks on the hump of the crude TRs were removed, and pure TRs were prepared. The chemical profile of the floating peaks was established using LC/MS, and the major compounds in this fraction were identified as apigenin glycosides, quercetin glycosides, kaempferol glycosides, theaflavins, theasinensin, and galloylglucoses based on the analysis of their tandem mass spectra and in comparison with literature data. This study will pave the way to further study the chemistry and biological activities of TRs and the health effects of black tea consumption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.