Evidence map›Paper›PMID 29859557›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2018

Defining Treatment Response and Remission in Youth Anxiety: A Signal Detection Analysis With the Multidimensional Anxiety Scale for Children.

Sophie A Palitz, Nicole E Caporino, Joseph F McGuire, John Piacentini, Anne Marie Albano, Boris Birmaher, John T Walkup, Scott N Compton, Golda S Ginsburg, Philip C Kendall

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. How well can commonly used anxiety scales detect treatment outcomes in the context of autism?Autism : the international journal of research and practice · 2025
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Psychometric propierties of the Selective Mutism Questionnaire in Spanish children.International journal of clinical and health psychology : IJCHP
    Article
  10. Using Evaluative Criteria to Review Youth Anxiety Measures, Part II: Parent-Report.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 1 country.

Sophie A PalitzTemple University, Philadelphia, PA. Electronic address: sophie.palitz@temple.edu.
Nicole E CaporinoAmerican University, Washington, DC.
Joseph F McGuireDivision of Child and Adolescent Psychiatry, Johns Hopkins University, Baltimore, MD.
John PiacentiniUniversity of California, Los Angeles School of Medicine.
Anne Marie AlbanoNew York State Psychiatric Institute and Columbia University Medical Center, NY.
Boris BirmaherUniversity of Pittsburgh School of Medicine, Pittsburgh, PA.
John T WalkupWeill Cornell Medicine and New York-Presbyterian Hospital, NY.
Scott N ComptonDuke University Medical Center, Durham, NC.
Golda S GinsburgUniversity of Connecticut Health Center, Storrs.
Philip C KendallTemple University, Philadelphia, PA.
Temple University · USAmerican University · USColumbia University Irving Medical Center · USDuke Medical Center · USJohns Hopkins University · USNewYork–Presbyterian Hospital · USUConn Health · USUniversity of California, Los Angeles · USUniversity of Pittsburgh · US

Funding

Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064089 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GINSBURG, GOLDA SUSAN · 2002 to 2007
$3.1M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064003 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS · 2002 to 2007
$2.7M
Child/Adolescent Anxiety Multimodal Treatment Study (CAMS)U01MH064092 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ALBANO, ANNE MARIE · 2002 to 2007
$2.4M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH063747 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI KENDALL, PHILIP C · 2002 to 2007
$2.2M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064088 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIACENTINI, JOHN C. · 2002 to 2007
$2.1M
3/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064089 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GINSBURG, GOLDA SUSAN, KEETON, COURTNEY PIERCE · 2010 to 2014
$925k
2/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064003 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SAKOLSKY, DARA JENNIFER · 2010 to 2014
$659k
4/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH063747 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI KENDALL, PHILIP C · 2010 to 2014
$618k
NIMH NIH HHS R01 MH063747NIMH NIH HHS R01 MH064003NIMH NIH HHS R01 MH064089NIMH NIH HHS U01 MH063747NIMH NIH HHS U01 MH064003NIMH NIH HHS U01 MH064088NIMH NIH HHS U01 MH064089
6 · The paper itself

Abstract

objectiveTo determine the percent reduction cutoffs on the Multidimensional Anxiety Scale for Children (MASC) that optimally predict treatment response and remission in youth with anxiety disorders.

methodYouths and their parents completed the MASC-C/P before and after treatment, and the Anxiety Disorders Interview Schedule for DSM-IV-Child and Parent Versions (ADIS-IV-C/P) and the Clinical Global Impression-Improvement Scale (CGI-I) were administered by independent evaluators. Treatment response and remission were defined by post-treatment ratings on the CGI-I and the ADIS-IV-C/P, respectively. Quality receiver operating characteristic methods determined the optimal cutoff on the MASC-P for predicting overall remission (loss of all study entry diagnoses) and optimal percent reductions on the MASC-P for predicting treatment response and remission of separation anxiety, social anxiety, and generalized anxiety.

resultsA post-treatment raw score of 42 optimally predicted remission. A reduction of 35% on the total MASC-P predicted treatment response. A reduction of 30% on the Separation Anxiety/Panic subscale of the MASC-P predicted separation anxiety remission. A reduction of 35% on the Social Anxiety subscale of the MASC-P predicted social anxiety remission. The MASC did not evidence a cutoff for remission of generalized anxiety disorder.

conclusionMASC cutoffs can facilitate comparison across studies and guide practice, aiding clinicians in assessing progress and informing treatment plans.

Indexed as

Predictive Value of TestsAnxiety DisordersChildHumansParentsPsychiatric Status Rating ScalesPsychometricsRecurrenceSignal Detection, Psychologicalchild anxietyclinical assessmentmeasurementMultidimensional Anxiety Scale for Childrentreatment outcome

Identifiers

PMID29859557
PMCPMC5988233
OpenAlexW2799983289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.