Evidence map›Paper›PMID 29859184›Full record

ArticleChest2018

In-Hospital Deaths Among Adults With Community-Acquired Pneumonia.

Grant W Waterer, Wesley H Self, D Mark Courtney, Carlos G Grijalva, Robert A Balk, Timothy D Girard, Sherene S Fakhran, Christopher Trabue, Paul McNabb, Evan J Anderson and 5 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Chest, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 53 citations in OpenAlex.

  1. Impact of multiplex respiratory virus testing on antimicrobial consumption in adults in acute care: a randomized clinical trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020
    Trial
  2. Glucocorticoid Treatment in Community-Acquired Pneumonia.Seminars in respiratory and critical care medicine · 2026
    Review
  3. Impact of pneumococcal urinary antigen testing on clinical outcomes in patients hospitalized with community-acquired pneumonia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  4. Article
  5. Article
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  11. Can Electronic Decision Support Tools Really Reduce Mortality from Community-acquired Pneumonia?American journal of respiratory and critical care medicine · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Advances in community-acquired pneumonia.Therapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 2 countries.

Grant W WatererUniversity of Western Australia, Perth, WA, Australia; Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address: grant.waterer@uwa.edu.au.
Wesley H SelfVanderbilt University Medical Center, Nashville, TN.
D Mark CourtneyNorthwestern University Feinberg School of Medicine, Chicago, IL.
Carlos G GrijalvaVanderbilt University Medical Center, Nashville, TN.
Robert A BalkRush University Medical Center, Chicago, IL.
Timothy D GirardUniversity of Pittsburgh School of Medicine, Pittsburgh, PA.
Sherene S FakhranJohn H. Stroger, Jr. Hospital of Cook County, Chicago, IL.
Christopher TrabueUniversity of Tennessee Health Science Center/Saint Thomas Health, Nashville, TN.
Paul McNabbUniversity of Tennessee Health Science Center/Saint Thomas Health, Nashville, TN.
Evan J AndersonEmory University School of Medicine, Atlanta, GA.
Derek J WilliamsVanderbilt University Medical Center, Nashville, TN.
Anna M BramleyCenters for Disease Control and Prevention, Atlanta, GA.
Seema JainCenters for Disease Control and Prevention, Atlanta, GA.
Kathryn M EdwardsVanderbilt University Medical Center, Nashville, TN.
Richard G WunderinkNorthwestern University Feinberg School of Medicine, Chicago, IL.
Vanderbilt University Medical Center · USCenters for Disease Control and Prevention · USNorthwestern University · USEmory University · USJohn H. Stroger, Jr. Hospital of Cook County · USRush University Medical Center · USSaint Thomas Health · USUniversity of Pittsburgh · USUniversity of Tennessee Health Science Center · USUniversity of Western Australia · AU

Funding

The Incidence and Etiology of Influenza-Associated Pneumonia in Hospitalized PersU18IP000299 · IP · VANDERBILT UNIVERSITY · PI EDWARDS, KATHRYN MARGARET · 2009 to 2010
$2.4M
Opioid selection and the risk of serious infections in older adultsR01AG043471 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G · 2013 to 2017
$2.3M
Salivary Cortisol as a Marker of Community-Acquired Pneumonia Severity in AdultsK23GM110469 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SELF, WESLEY H · 2015 to 2018
$683k
NCIRD CDC HHS U18 IP000299NIA NIH HHS R01 AG043471NIGMS NIH HHS K23 GM110469
6 · The paper itself

Abstract

backgroundAdults hospitalized with community-acquired pneumonia (CAP) are at high risk for short-term mortality. However, it is unclear whether improvements in in-hospital pneumonia care could substantially lower this risk. We extensively reviewed all in-hospital deaths in a large prospective CAP study to assess the cause of each death and assess the extent of potentially preventable mortality.

methodsWe enrolled adults hospitalized with CAP at five tertiary-care hospitals in the United States. Five physician investigators reviewed the medical record and study database for each patient who died to identify the cause of death, the contribution of CAP to death, and any preventable factors potentially contributing to death.

resultsAmong 2,320 enrolled patients, 52 (2.2%) died during initial hospitalization. Among these 52 patients, 33 (63.4%) were ≥ 65 years old, and 32 (61.5%) had ≥ two chronic comorbidities. CAP was judged to be the direct cause of death in 27 patients (51.9%). Ten patients (19.2%) had do-not-resuscitate orders prior to admission. Four patients were identified in whom a lapse in quality of care potentially contributed to death; preexisting end-of-life limitations were present in two of these patients. Two patients seeking full medical care experienced a lapse in in-hospital quality of pneumonia care that potentially contributed to death.

conclusionsIn this study of adults with CAP at tertiary-care hospitals with a low mortality rate, most in-hospital deaths did not appear to be preventable with improvements in in-hospital pneumonia care. Preexisting end-of-life limitations in care, advanced age, and high comorbidity burden were common among those who died.

Indexed as

Hospital MortalityAdultAgedAged, 80 and overCause of DeathCommunity-Acquired InfectionsFemaleHumansMaleMiddle AgedPneumoniaProspective StudiesRisk FactorsUnited Statesmortalitypneumoniaquality of care

Identifiers

PMID29859184
PMCPMC6859251
OpenAlexW2807550063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.