Evidence map›Paper›PMID 29859117›Full record

ArticleMolecular brain2018

GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.

Dong-Yun Jiang, Zheng Wu, Cody Tieu Forsyth, Yi Hu, Siu-Pok Yee, Gong Chen

Open access · goldAbstract read
In one paragraph

Article in Molecular brain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission.International journal of molecular sciences · 2022
    Review
  8. Review
  9. Article
  10. GABAergic System Dysfunction in Autism Spectrum Disorders.Frontiers in cell and developmental biology · 2021
    Review
  11. Synaptic recognition molecules in development and disease.Current topics in developmental biology · 2021
    Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dong-Yun JiangDepartment of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA.
Zheng WuDepartment of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA.
Cody Tieu ForsythDepartment of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA.
Yi HuDepartment of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA.
Siu-Pok YeeDepartment of Cell Biology, University of Connecticut Health center, Farmington, CT, 06030, USA.
Gong ChenDepartment of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA. gongchen@psu.edu.ORCID 0000-0002-1857-3670
Pennsylvania State University · USUConn Health · US

Funding

GABAergic Synapse Assembly: Extrasynaptic GABAAR TargetingR01MH083911 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI CHEN, GONG · 2010 to 2014
$1.8M
Functional Analysis of Neuroligin-2 Mutations in SchizophreniaR21MH092740 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI CHEN, GONG · 2011 to 2012
$402k
NIMH NIH HHS MH083911NIMH NIH HHS MH092740NIMH NIH HHS R01 MH083911NIMH NIH HHS R21 MH092740
6 · The paper itself

Abstract

Schizophrenia (SCZ) is a severe mental disorder characterized by delusion, hallucination, and cognitive deficits. We have previously identified from schizophrenia patients a loss-of-function mutation Arg

Indexed as

Behavior, AnimalAnimalsCell Adhesion Molecules, NeuronalDisease Models, Animalgamma-Aminobutyric AcidHippocampusHumansMice, TransgenicMutationNerve Tissue ProteinsNeuronsSchizophreniaStress, PhysiologicalSynapsesSynaptic TransmissionCell Adhesion Molecules, Neuronalgamma-Aminobutyric AcidNerve Tissue Proteinsneuroligin 2GABAMouse modelMutationNeuroligin-2Schizophrenia

Identifiers

PMID29859117
PMCPMC5984814
OpenAlexW2781320294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.