ArticleAnnals of clinical microbiology and antimicrobials2018
Association of virulence gene expression with colistin-resistance in Acinetobacter baumannii: analysis of genotype, antimicrobial susceptibility, and biofilm formation.
Article in Annals of clinical microbiology and antimicrobials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
- Antibiotic Resistance and Biofilm-Forming Capacity of Oral Biofilm Bacteria in Patients With Periodontitis and Healthy Individuals.MicrobiologyOpen · 2026Article
- Molecular and virulence characteristics of carbapenem-resistant Acinetobacter baumannii isolates: a prospective cohort study.Scientific reports · 2023Article
- Synergistic Role of Biofilm-Associated Genes and Efflux Pump Genes in Tigecycline Resistance of Acinetobacter baumannii.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Phenotypic and Genotypic Investigation of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- The Prevalence of Virulence Factor Genes among Carbapenem-Non-SusceptibleDiagnostics (Basel, Switzerland) · 2023Article
- Contribution of antimicrobial photo-sonodynamic therapy in wound healing: an in vivo effect of curcumin-nisin-based poly (L-lactic acid) nanoparticle on Acinetobacter baumannii biofilms.BMC microbiology · 2022Article
- Epidemiological and genomic characteristics of globalFrontiers in microbiology · 2022Article
- Molecular typing and antibiotic resistance patterns among clinical isolates ofFrontiers in microbiology · 2022Article
- MCR Expression Conferring Varied Fitness Costs on Host Bacteria and Affecting Bacteria Virulence.Antibiotics (Basel, Switzerland) · 2021Article
- Frequency of Multi-Drug Resistance and Molecular Characteristics of Resistance to Colistin inTanaffos · 2021Article
- Molecular detection of Extended-Spectrum β-lactamases (ESBLs) and biofilm formation in uropathogenMedical journal of the Islamic Republic of Iran · 2021Article
- Epidemiology of Biofilm ProducingInfection and drug resistance · 2021Article
- Genotyping and molecular characterization of clinicalPathogens and global health · 2020Article
- Molecular Characterization of Carbapenem/Colistin-ResistantInfection and drug resistance · 2020Article
- Survey on Genetic Diversity, Biofilm Formation, and Detection of Colistin Resistance Genes in Clinical Isolates ofInfection and drug resistance · 2020Article
- Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach.Frontiers in microbiology · 2019Review
- Evaluation of Antimicrobial Activity of Novel Chimeric M-PEX12 Peptide AgainstIranian journal of pharmaceutical research : IJPRArticle
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7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAcinetobacter baumannii causes difficult-to-treat nosocomial infections, which often lead to morbidity due to the development of antimicrobial drug resistance and expression of virulence genes. Data regarding the association of resistance to colistin, a last treatment option, and the virulence gene expression of A. baumannii is scarce.
methodsWe evaluated the MLVA genotype, antimicrobial resistance, and biofilm formation of 100 A. baumannii isolates from burn patients, and further compared the in vitro and in vivo expression of four virulence genes among five colistin-resistant A. baumannii (Cst-R-AB) isolates. Five Cst-R-AB isolates were tested; one from the present study, and four isolated previously.
resultsOur results showed that reduced expression of recA, along with increased in vivo expression of lpsB, dnaK, and blsA; are associated with colistin resistance among Cst-R-AB isolates. Differences in virulence gene expressions among Cst-R-AB isolates, may in part explain common discrepant in vitro vs. in vivo susceptibility data during treatment of infections caused by Cst-R-AB.
conclusionsOur findings highlight the intricate relationship between colistin-resistance and virulence among A. baumannii isolates, and underscore the importance of examining the interactions between virulence and antimicrobial resistance toward efforts to control the spread of multidrug-resistant A. baumannii (MDR-AB) isolates, and also to reduce disease severity in burn patients with MDR-AB infection.
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