SynthesisBMC musculoskeletal disorders2018
Dose-response relationship between cumulative physical workload and osteoarthritis of the hip - a meta-analysis applying an external reference population for exposure assignment.
Synthesis in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Hip osteoarthritis and occupational mechanical exposures: a systematic review and meta-analysis.Scandinavian journal of work, environment & health · 2024Pooled it
- Work-relatedness of inguinal hernia: a systematic review including meta-analysis and GRADE.Hernia : the journal of hernias and abdominal wall surgery · 2020Pooled it
- Risk factors for development of lower limb osteoarthritis in physically demanding occupations: A narrative umbrella review.Journal of occupational health · 2020Pooled it
- Exposure-Response Relationship and Doubling Risk Doses-A Systematic Review of Occupational Workload and Osteoarthritis of the Hip.International journal of environmental research and public health · 2019Pooled it
- Physically demanding occupations among females and sex-related differences to develop osteoarthritis of the hip: a systematic review and meta-analysis.Journal of occupational medicine and toxicology (London, England) · 2024Article
- Comparing risk assessment methods for work-related musculoskeletal disorders with in vivo joint loads during manual materials handling.Scientific reports · 2024Observational
- A Health-Impact Assessment of an Ergonomic Measure to Reduce the Risk of Work-Related Lower Back Pain, Lumbosacral Radicular Syndrome and Knee Osteoarthritis among Floor Layers in The Netherlands.International journal of environmental research and public health · 2023Article
- A first step towards a framework for interventions for individual working practice to prevent work-related musculoskeletal disorders: a scoping review.BMC musculoskeletal disorders · 2023Article
- Influence of physically demanding occupations on the development of osteoarthritis of the hip: a systematic review.Journal of occupational medicine and toxicology (London, England) · 2022Review
- WOMAC score and arthritis diagnosis predict decreased agricultural productivity.BMC musculoskeletal disorders · 2021Article
- Diagnostic criteria for musculoskeletal disorders for use in occupational healthcare or research: a scoping review of consensus- and synthesised-based case definitions.BMC musculoskeletal disorders · 2021Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is consistent evidence from observational studies of an association between occupational lifting and carrying of heavy loads and the diagnosis of hip osteoarthritis. However, due to the heterogeneity of exposure estimates considered in single studies, a dose-response relationship between cumulative physical workload and hip osteoarthritis could not be determined so far.
methodsThis study aimed to analyze the dose-response relationship between cumulative physical workload and hip osteoarthritis by replacing the exposure categories of the included studies with cumulative exposure values of an external reference population. Our meta-regression analysis was based on a recently conducted systematic review (Bergmann A, Bolm-Audorff U, Krone D, Seidler A, Liebers F, Haerting J, Freiberg A, Unverzagt S, Dtsch Arztebl Int 114:581-8, 2017). The main analysis of our meta-regression comprised six case-control studies for men and five for women. The population control subjects of a German multicentre case-control study (Seidler A, Bergmann A, Jäger M, Ellegast R, Ditchen D, Elsner G, Grifka J, Haerting J, Hofmann F, Linhardt O, Luttmann A, Michaelis M, Petereit-Haack G, Schumann B, Bolm-Audorff U, BMC Musculoskelet Disord 10:48, 2009) served as the reference population. Based on the sex-specific cumulative exposure percentiles of the reference population, we assigned exposure values to each category of the included studies using three different cumulative exposure parameters. To estimate the doubling dose (the amount of physical workload to double the risk of hip osteoarthritis) on the basis of all available case-control-studies, meta-regression analyses were conducted based on the linear association between exposure values of the reference population and the logarithm of reported odds ratios (ORs) from the included studies.
resultsIn men, the risk to develop hip osteoarthritis was increased by an OR of 1.98 (95% CI 1.20-3.29) per 10,000 tons of weights ≥20 kg handled, 2.08 (95% CI 1.22-3.53) per 10,000 tons handled > 10 times per day and 8.64 (95% CI 1.87-39.91) per 10
conclusionsUnder specific conditions, the application of an external reference population allows for the derivation of a dose-response relationship despite high exposure heterogeneities in the pooled studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.