ArticleBMC psychiatry2018
Compromised dynamic cerebral autoregulation in patients with generalized anxiety disorder: a study using transfer function analysis.
Article in BMC psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comorbidity Patterns in Patients Newly Diagnosed With Colorectal Cancer: Network-Based Study.JMIR public health and surveillance · 2023Observational
- Microbiota-ear-brain interaction is associated with generalized anxiety disorder through activation of inflammatory cytokine responses.Frontiers in immunology · 2023Article
- Effects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Dynamic Cerebral Autoregulation Remains Stable During the Daytime (8 a.m. to 8 p.m.) in Healthy Adults.Frontiers in physiology · 2018Article
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Authors and funding
8 authors.
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Abstract
backgroundPatients with generalized anxiety disorder (GAD) usually present with various neurological symptoms, but the mechanisms remain unclear. We aimed to analyze the characteristics of dynamic cerebral autoregulation (dCA) in patients with GAD.
methodsPatients (aged ≥18 years) who were diagnosed with GAD were enrolled in this study. Medically and psychiatrically healthy volunteers were recruited as controls. Subjects received the Hamilton Rating Scale for Anxiety (HAMA) and 17-item Hamilton Depression Rating Scale (HAMD) evaluation. Noninvasive continuous arterial blood pressure and bilateral middle cerebral artery blood flow velocity were recorded simultaneously from each subject. Transfer function analysis was used to derive the autoregulatory parameters, including phase difference, gain, and coherence function.
resultsA total of 57 patients with GAD and 40 healthy volunteers were enrolled. We found that the phase difference values were significantly compromised in patients with GAD. In the Spearman correlation analysis, the phase difference values were negatively correlated with the HAMA scores and the HAMD scores. In the multiple linear regression analysis, GAD is negatively correlated with the phase difference values, whereas age is positively correlated with the phase difference values.
conclusionsOur results suggested that the dCA was compromised in patients with GAD and negatively correlated with the score of anxiety. Improving the dCA may be a potential therapeutic method for treating the neurological symptoms of GAD patients.
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