Evidence map›Paper›PMID 29859046›Full record

SynthesisBMC nephrology2018

Burden of chronic kidney disease on the African continent: a systematic review and meta-analysis.

Arnaud D Kaze, Titilayo Ilori, Bernard G Jaar, Justin B Echouffo-Tcheugui

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06312072 (Understanding Risk Factors for Progressive Chronic Kidney Disease in Malawi to Inform Interventions for Earlier Detection and Prevention), which is not on this map. Cited by 131 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06312072 unknown statusnot on this mapstarted 2024, after this paper: background citation

Understanding Risk Factors for Progressive Chronic Kidney Disease in Malawi to Inform Interventions for Earlier Detection and Prevention (Impso Study)

TypeobservationalSponsorLiverpool School of Tropical MedicineRan2024 to 2025Enrolled1,100ConditionsChronic Kidney Diseases, Non-Communicable Chronic Diseases, Non-communicable Disease, Kidney DiseasesArmsNo intervention, observational study
3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arnaud D KazeDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Titilayo IloriDivision of Renal Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Bernard G JaarDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Justin B Echouffo-TcheuguiDivision of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA. jechouffotcheugui@bwh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate contemporary data on the burden of Chronic Kidney Disease (CKD) on the African continent are lacking. We determined the prevalence of CKD in adult populations living in Africa, and variations by stage, gender, estimated Glomerular Filtration Rate (eGFR) equation, and residence.

methodsFor this systematic review, we searched multiple electronic databases for original studies on CKD prevalence reported from January 1, 2000 to December 31, 2016. Two reviewers independently undertook quality assessment and data extraction. We stabilized the variance of study-specific estimates with the Freeman-Turkey single arcsine transformation and pooled the data using a random effects meta-analysis models.

resultsA total of 98 studies involving 98,432 individuals were included in the final meta-analysis. The overall prevalence was 15.8% (95% CI 12.1-19.9) for CKD stages 1-5 and 4.6% (3.3-6.1) for CKD stages 3-5 in the general population. Equivalent figures were greater at 32.3% (23.4-41.8) and 13.3% (10.7-16.0) in high-risk populations (people with hypertension, diabetes, HIV). CKD prevalence was higher in studies based on the Cockcroft-Gault formula than MDRD or CKD-EPI equations; and in studies from sub-Saharan Africa compared with those from North Africa (17.7, 95% CI 13.7-22.1 vs 6.1, 95% CI 3.6-9.3, p < 0.001). There was substantial heterogeneity across studies (all I

conclusionCKD is highly prevalent across Africa, inviting efforts into prevention, early detection and control of CKD in adults living on the African continent which is particularly important in a resource limited environment.

trial registrationProspero Registration ID: CRD42017054445 .

Indexed as

Black PeopleCost of IllnessAfricaCohort StudiesCross-Sectional StudiesDiabetes MellitusGlomerular Filtration RateHumansHypertensionRandomized Controlled Trials as TopicRenal Insufficiency, ChronicRisk FactorsAfricaChronic kidney diseaseMeta-analysisPrevalenceSystematic review

Identifiers

PMID29859046
PMCPMC5984759

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.