ArticleDrug delivery and translational research2018
Skin drug permeability and safety through a vibrating solid micro-needle system.
Article in Drug delivery and translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Microneedles in biomedicine: Innovations, challenges, and future prospects.Biomaterials translational · 2025Review
- Comparative study of permeation effects between vibrating microneedle and low-frequency sonophoresis systems.Drug delivery and translational research · 2024Article
- Microneedle-mediated treatment for superficial tumors by combining multiple strategies.Drug delivery and translational research · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Micro-needles and sonophoresis are two physical methods for enhancing skin permeation for transdermal drug delivery. A solid micro-needle system with vertical vibration was integrated and its effects on transdermal drug delivery were studied. Evan's blue (EB) staining and histological evaluation were performed to reveal the skin morphology and micro-conduits created by vibrating micro-needles. Trans-epidermal water loss (TEWL) and infection studies on rat's skin after vibrating micro-needle treatment were performed to evaluate the safety of the treatment. In vivo insulin delivery and tetramethylpyrazine hydrochloride (TMPH) permeation were carried out to assess the effectiveness of the transdermal drug delivery using the vibrating micro-needle system. The structural integrity of vibrated micro-needles was studied through SEM photos. EB staining observation showed that EB has diffused significantly on the skin surface treated with vibrating micro-needles. The micro-conduits were seen by histological visualization. TEWL values increased significantly after treatment as vibration frequency increased. The infection evaluation showed a slight increase of white blood cell number resulted from vibrating micro-needle treatment. The in vivo insulin absorption experiment demonstrated an enhanced transdermal delivery of insulin through vibrating micro-needles treatment, and the effectiveness of blood glucose level increased with increasing vibration frequency. The TMPH permeation study showed an obvious enhanced skin permeability due to vibrating micro-needle pretreatment. The degree of enhancement also increased with vibration frequency. No broken tip of vibrated micro-needle was found after application. The vibrating solid micro-needle was effective and safe for the transdermal administration of hydrophilic drugs. The effectiveness increases with increasing vibration frequency.
Indexed as
Identifiers
29858819What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.