ArticleMycopathologia2018
TR34/L98H Mutation in CYP51A Gene in Aspergillus fumigatus Clinical Isolates During Posaconazole Prophylaxis: First Case in Korea.
Article in Mycopathologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 22 citations in OpenAlex.
- Efficacy and safety of combination antifungal therapy in Korean haematological patients with invasive aspergillosis.Mycoses · 2019Trial
- Global epidemiology of azole resistance inJAC-antimicrobial resistance · 2026Review
- Understanding multi-azole resistance inFrontiers in fungal biology · 2026Article
- Activity of Azole and Non-Azole Substances AgainstInternational journal of molecular sciences · 2025Article
- Management of Invasive Bronchopulmonary Mucormycosis with Low-Dose Antifungal Therapy and Left Lower Lobectomy in a Patient with Renal Insufficiency.Infection and drug resistance · 2025Article
- Genetic Diversity and Azole Resistance Among Natural Aspergillus fumigatus Populations in Yunnan, China.Microbial ecology · 2022Article
- Treatment of a Pulmonary Aspergilloma in a Lung Transplant Recipient Using Catheter-directed Intracavitary Instillation of Liposomal Amphotericin B.Transplantation direct · 2022Article
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- Mycopathologia 2020: Legacy and Change to Remain Relevant for Content, Creation, and Communication.Mycopathologia · 2021Article
- Article
- Identification of Fungal Species and Detection of Azole-Resistance Mutations in theYonsei medical journal · 2020Article
- Antifungal Susceptibility Tests and theMycobiology · 2020Article
- Contemporary Gene Flow is a Major Force Shaping the Aspergillus fumigatus Population in Auckland, New Zealand.Mycopathologia · 2019Article
- Emerging Fungal Infections: New Patients, New Patterns, and New Pathogens.Journal of fungi (Basel, Switzerland) · 2019Review
- Epidemiology and Antifungal Susceptibility Profile ofJournal of clinical microbiology · 2019Article
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Azole resistance in Aspergillus fumigatus is an emerging problem, especially in immunocompromised patients. It has been reported worldwide, including in Asia, but has not yet been reported in Korea. Here, we report a case of invasive pulmonary aspergillosis (IPA) caused by azole-resistant A. fumigatus that developed in a hematopoietic stem cell transplantation recipient during posaconazole prophylaxis for immunosuppressive therapy of graft-versus-host diseases. We identified TR34/L98H/S297T/F495L mutation in the CYP51A gene of A. fumigatus clinical isolate obtained from bronchial washing fluid. Minimal inhibitory concentrations for itraconazole, voriconazole, and posaconazole were > 16, 1, and 4 μg/mL, respectively. While IPA improved partially under voriconazole treatment, the patient died from carbapenemase-producing Klebsiella pneumoniae bacteremia. Further epidemiological surveillance studies are warranted.
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