ArticleBreast cancer research and treatment2018
Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer-specific survival.
Article in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Biomechanical parameters quantified by MR elastography for predicting response to neoadjuvant chemotherapy and disease-free survival in breast cancer: a prospective longitudinal study.Breast cancer research : BCR · 2025Article
- Evaluation of Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer through Shear-Wave Elastography.Current medical imaging · 2025Observational
- Shear Wave Elastography: A Non-Invasive Approach for Assessing TGF-β1/MAPK Signaling Molecules and EMT in Breast Cancer.Breast cancer (Dove Medical Press) · 2025Article
- Article
- Strain ultrasonic elastography imaging features of locally advanced breast cancer: association with response to neoadjuvant chemotherapy and recurrence-free survival.BMC medical imaging · 2023Article
- Assessment of ultrasound shear wave elastography: An animal ex-vivo study.Journal of applied clinical medical physics · 2023Article
- Article
- Prediction of clinical response to neoadjuvant therapy in advanced breast cancer by baseline B-mode ultrasound, shear-wave elastography, and pathological information.Frontiers in oncology · 2023Article
- A paired comparison of nerve dimensions using B-Mode ultrasound and shear wave elastography during regional anaesthesia.Ultrasound (Leeds, England) · 2022Article
- Preoperative neoadjuvant chemotherapy in patients with breast cancer evaluated using strain ultrasonic elastography.World journal of clinical cases · 2022Article
- Stiffness of tongue squamous cell carcinoma measured using strain elastography correlates with the amount of collagen fibers in the tumor.Oral radiology · 2022Article
- The value of prognostic ultrasound features of breast cancer in different molecular subtypes with a focus on triple negative disease.Breast cancer (Tokyo, Japan) · 2022Article
- Tumor stiffness measured by shear-wave elastography: association with disease-free survival in women with early-stage breast cancer.The British journal of radiology · 2021Article
- Tumor elastography and its association with cell-free tumor DNA in the plasma of breast tumor patients: a pilot study.Quantitative imaging in medicine and surgery · 2021Article
- Article
- Tumor stiffness measured by shear wave elastography correlates with tumor hypoxia as well as histologic biomarkers in breast cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- Why is renal impairment associated with poorer cancer specific survival in breast cancer patients?: a comparison with patients with other comorbidities.International journal of clinical oncology · 2020Article
- Association of sonographic features and molecular subtypes in predicting breast cancer disease outcomes.Cancer medicine · 2020Article
- Dynamic interactions between the extracellular matrix and estrogen activity in progression of ER+ breast cancer.Oncogene · 2019Article
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10 authors.
Funding
Abstract
introductionWith the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).
methodsA consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.
resultsOf the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P = 0.0001). HR for 2 groups based on US size < or ≥ 20 mm were 1 and 5.1 (P < 0.0001). HR for each unit increase in tumour grade on core biopsy was 3.9 (P < 0.0001). The HR for ER positivity compared to ER negativity was 0.21 (P < 0.001). BCSS was also associated with presentation mode and pre-operative nodal status. In a multivariable model, stiffness, US size and ER status were independently associated with BCSS.
conclusionMultiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions.
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