Evidence map›Paper›PMID 29858738›Full record

ArticleThe AAPS journal2018

Vaccine Adjuvant Incorporation Strategy Dictates Peptide Amphiphile Micelle Immunostimulatory Capacity.

Rui Zhang, Jake S Kramer, Josiah D Smith, Brittany N Allen, Caitlin N Leeper, Xiaolei Li, Logan D Morton, Fabio Gallazzi, Bret D Ulery

Abstract read
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Article in The AAPS journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Biomaterials for vaccine-based cancer immunotherapy.Journal of controlled release : official journal of the Controlled Release Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rui ZhangDepartment of Chemical Engineering, University of Missouri, W2027 Lafferre Hall, 416 S. 6th Street, Columbia, Missouri, 65211, USA.
Jake S KramerDepartment of Biochemistry, University of Missouri, Columbia, Missouri, 65211, USA.
Josiah D SmithDepartment of Chemical Engineering, University of Missouri, W2027 Lafferre Hall, 416 S. 6th Street, Columbia, Missouri, 65211, USA.
Brittany N AllenDepartment of Bioengineering, University of Missouri, Columbia, Missouri, 65211, USA.
Caitlin N LeeperDepartment of Chemical Engineering, University of Missouri, W2027 Lafferre Hall, 416 S. 6th Street, Columbia, Missouri, 65211, USA.
Xiaolei LiDepartment of Chemical Engineering, University of Missouri, W2027 Lafferre Hall, 416 S. 6th Street, Columbia, Missouri, 65211, USA.
Logan D MortonDepartment of Chemical Engineering, University of Missouri, W2027 Lafferre Hall, 416 S. 6th Street, Columbia, Missouri, 65211, USA.
Fabio GallazziMolecular interactions Core, University of Missouri, Columbia, Missouri, 65211, USA.
Bret D UleryDepartment of Chemical Engineering, University of Missouri, W2027 Lafferre Hall, 416 S. 6th Street, Columbia, Missouri, 65211, USA. uleryb@missouri.edu.ORCID 0000-0003-0854-1859

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current vaccine research has shifted from traditional vaccines (i.e., whole-killed or live-attenuated) to subunit vaccines (i.e., protein, peptide, or DNA) as the latter is much safer due to delivering only the bioactive components necessary to produce a desirable immune response. Unfortunately, subunit vaccines are very weak immunogens requiring delivery vehicles and the addition of immunostimulatory molecules termed adjuvants to convey protective immunity. An interesting type of delivery vehicle is peptide amphiphile micelles (PAMs), unique biomaterials where the vaccine is part of the nanomaterial itself. Due to the modularity of PAMs, they can be readily modified to deliver both vaccine antigens and adjuvants within a singular construct. Through the co-delivery of a model antigenic epitope (Ovalbumin

Indexed as

Adjuvants, ImmunologicAnimalsDrug Delivery SystemsEpitopesImmunogenicity, VaccineMicellesPeptidesSurface-Active AgentsVaccines, SubunitAdjuvants, ImmunologicEpitopesMicellesPeptidesSurface-Active AgentsVaccines, SubunitAdjuvantCo-localizationPeptide amphiphile micellesSubunit vaccines

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.