Viewpoint planning for quantitative coronary angiography.

purposeIn coronary angiography, the condition of myocardial blood supply is assessed by analyzing 2-D X-ray projections of contrasted coronary arteries. This is done using a flexible C-arm system. Due to the X-ray immanent dimensionality reduction projecting the 3-D scene onto a 2-D image, the viewpoint is critical to guarantee an appropriate view onto the affected artery and, thus, enable reliable diagnosis. In this work, we introduce an algorithm computing optimal viewpoints for the assessment of coronary arteries without the need for 3-D models.

methodsWe introduce the concept of optimal viewpoint planning solely based on a single angiographic X-ray image. The subsequent viewpoint is computed such that it is rotated precisely around a vessel, while minimizing foreshortening.

resultsOur algorithm reduces foreshortening substantially compared to the input view and completely eliminates it for [Formula: see text] rotations. Rotations around isocentered foreshortening-free vessels passing the isocenter are exact. The precision, however, decreases when the vessel is off-centered or foreshortened. We evaluate worst-case boundaries, providing insight in the maximal inaccuracies to be expected. This can be utilized to design viewpoints guaranteeing desired requirements, e.g., a true rotation around the vessel of at minimum [Formula: see text]. In addition, a phantom study is performed investigating the impact of input views to 3-D quantitative coronary angiography (QCA).

conclusionWe introduce an algorithm for optimal viewpoint planning from a single angiographic X-ray image. The quality of the second viewpoint-i.e., vessel foreshortening and true rotation around vessel-depends on the first viewpoint selected by the physician; however, our computed viewpoint is guaranteed to reduce the initial foreshortening. Our novel approach uses fluoroscopy images only and, thus, seamlessly integrates with the current clinical workflow for coronary assessment. In addition, it can be implemented in the QCA workflow without increasing user interaction, making vessel-shape reconstruction more stable by standardizing viewpoints.