Trial reportClinical oral investigations2019
Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal.
Trial report in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Fluoride varnish, ozone and octenidine reduce the incidence of white spot lesions and caries during orthodontic treatment: randomized controlled trial.Scientific reports · 2022Trial
- Treatment of symptomatic, deep, almost cariously exposed lesions using ozone.Scientific reports · 2021Trial
- Influence of ozone application in the stepwise excavation of primary molars: a randomized clinical trial.Clinical oral investigations · 2020Trial
- Effectiveness of the ozone application in two-visit indirect pulp therapy of permanent molars with deep carious lesion: a randomized clinical trial.Clinical oral investigations · 2019Trial
- The Potential of Ozone Therapy as an Adjunct to Periodontal Treatment in Diabetes Mellitus: A Biomarkers Scoping Review.Current diabetes reviews · 2026Article
- Chemomechanical Caries Removal with Enzymatic Technology: A ComparativeInternational journal of clinical pediatric dentistry · 2025Article
- Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review).Biomedical reports · 2024Review
- Ozone Therapy in Medicine and Dentistry: A Review of the Literature.Dentistry journal · 2023Review
- Efficacy of antiseptics and chemomechanical methods for dentin caries lesions: A systematic review with GRADE approach.Frontiers in oral health · 2023Review
- Review
- Antimicrobial Effect of Ozone Therapy in Deep Dentinal Carious Lesion: A Systematic Review.International journal of clinical pediatric dentistry · 2022Review
- Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry.Nanomaterials (Basel, Switzerland) · 2021Review
- Ozone ultrafine bubble water induces the cellular signaling involved in oxidative stress responses in human periodontal ligament fibroblasts.Science and technology of advanced materials · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo evaluate local effect of gaseous ozone on bacteria in deep carious lesions after incomplete caries removal, using chlorhexidine as control, and to investigate its effect on pulp vascular endothelial growth factor (VEGF), neuronal nitric oxide synthase (nNOS), and superoxide dismutase (SOD). MATERIALS AND
methodsAntibacterial effect was evaluated in 48 teeth with diagnosed deep carious lesion. After incomplete caries removal, teeth were randomly allocated into two groups regarding the cavity disinfectant used: ozone (open system) or 2% chlorhexidine. Dentin samples were analyzed for the presence of total bacteria and Lactobacillus spp. by real-time quantitative polymerase chain reaction. For evaluation of ozone effect on dental pulp, 38 intact permanent teeth indicated for pulp removal/tooth extraction were included. After cavity preparation, teeth were randomly allocated into two groups: ozone group and control group. VEGF/nNOS level and SOD activity in dental pulp were determined by enzyme-linked immunosorbent assay and spectrophotometric method, respectively.
resultsOzone application decreased number of total bacteria (p = 0.001) and Lactobacillus spp. (p < 0.001), similarly to chlorhexidine. The VEGF (p < 0.001) and nNOS (p = 0.012) levels in dental pulp after ozone application were higher, while SOD activity was lower (p = 0.001) comparing to those in control pulp.
conclusionsAntibacterial effect of ozone on residual bacteria after incomplete caries removal was similar to that of 2% chlorhexidine. Effect of ozone on pulp VEGF, nNOS, and SOD indicated its biocompatibility. CLINICAL RELEVANCE: Ozone appears as effective and biocompatible cavity disinfectant in treatment of deep carious lesions by incomplete caries removal technique.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.