Evidence map›Paper›PMID 29858631›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

The associations between the changes in serum inflammatory markers and bone mineral accrual in boys with overweight and obesity during pubertal maturation: a 3-year longitudinal study in Estonian boys.

E Mengel, V Tillmann, L Remmel, P Kool, P Purge, E Lätt, J Jürimäe

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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  3. Advances in laboratory medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

E MengelInstitute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Jakobi 5, 50411, Tartu, Estonia. evamengel0@gmail.com.ORCID http://orcid.org/0000-0003-4693-7416
V TillmannChildren's Clinic of Tartu University Hospital, Tartu, Estonia.
L RemmelInstitute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Jakobi 5, 50411, Tartu, Estonia.
P KoolInstitute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.
P PurgeInstitute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Jakobi 5, 50411, Tartu, Estonia.
E LättInstitute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Jakobi 5, 50411, Tartu, Estonia.
J JürimäeInstitute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Jakobi 5, 50411, Tartu, Estonia.

Funding

Eesti Teadusagentuur PUT 1382Estonian Ministry of Education and Science IUT 20-58
6 · The paper itself

Abstract

Adipose tissue produces different inflammatory cytokines which compromise bone mineral accrual during puberty. Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), interleukin (IL)-8, and interferon-gamma (IFN-γ) are significantly related to bone mineral accrual during pubertal maturation in boys with different BMI values.

introductionThis longitudinal study aims to identify the inflammatory markers that most strongly associate with pubertal bone mineral density (BMD) increment in boys with overweight and obesity (OWB).

methodsTwenty-six OWB and 29 normal-weight boys were followed yearly for 3 years to measure changes in 12 serum inflammatory markers, BMD (by DXA), and apparent volumetric BMD. The OWB group was further divided into two subgroups according to their BMI gain during the 3-year period. Data through time points presented as slopes were used to calculate correlation coefficients to explore the possible relationships between variables of interest. In the whole study group, linear mixed effects (LME) models were also used.

resultsIncrement in serum VEGF concentration was inversely associated with an increase in total body (TB) BMD (r = - 0.82, P = 0.02) and TB bone mineral content (BMC)/height (r = - 0.82, P = 0.02) in those OWB whose BMI gain was higher during pubertal years. In the whole study group, the LME model confirmed the inverse association between VEGF and TB BMC/height (P < 0.05). EGF was inversely associated with LS BMD and LS BMAD (P < 0.05), whereas there was a positive association between IL-8 and TB BMAD and between IFN-γ and LS BMD (P < 0.05).

conclusionsLower increment in BMD in OWB with higher BMI gain is associated with increasing serum VEGF concentration during pubertal maturation. VEGF, EGF, IL-8, and IFN-γ are significantly associated with BMD during pubertal maturation in boys with different BMI values.

Indexed as

AnthropometryBiomarkersBody Mass IndexChildCytokinesEpidermal Growth FactorHumansInflammation MediatorsLongitudinal StudiesMaleObesityOverweightPubertySexual MaturationTestosteroneVascular Endothelial Growth Factor ABiomarkersCytokinesEpidermal Growth FactorInflammation MediatorsTestosteroneVascular Endothelial Growth Factor AVEGFA protein, humanBody mass indexBone mineral densityBoysCytokinesInflammationPuberty

Identifiers

PMID29858631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.