Evidence map›Paper›PMID 29858572›Full record

ArticleNature communications2018

Cellular conditions of weakly chelated magnesium ions strongly promote RNA stability and catalysis.

Ryota Yamagami, Jamie L Bingaman, Erica A Frankel, Philip C Bevilacqua

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 80 citations in OpenAlex.

  1. RNA therapeutics: current status and future directions.Signal transduction and targeted therapy · 2026
    Review
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  3. Review
  4. Optimized tRNA structure-seq reveals robust tRNA secondary structures inbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Computational De Novo Design of Group II Introns Yields Highly Active Ribozymes.Chembiochem : a European journal of chemical biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Preanalytical Impact of Incomplete KDiagnostics (Basel, Switzerland) · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Regulating DNA-Hybridization Using a Chemically Fueled Reaction Cycle.Journal of the American Chemical Society · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ryota YamagamiDepartment of Chemistry, Pennsylvania State University, University Park, PA, 16802, USA.
Jamie L BingamanDepartment of Chemistry, Pennsylvania State University, University Park, PA, 16802, USA.
Erica A FrankelDepartment of Chemistry, Pennsylvania State University, University Park, PA, 16802, USA.
Philip C BevilacquaDepartment of Chemistry, Pennsylvania State University, University Park, PA, 16802, USA. pcb5@psu.edu.
Pennsylvania State University · USDow Chemical (United States) · US

Funding

Overall (pp. 40-62)P41GM103485 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2012 to 2018
$15.5M
RNA folding and catalysis at the interface of biophysics and genomicsR35GM127064 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PHILIP C BEVILACQUA · 2018 to 2026
$3.4M
RNA Folding and Adaptation in a Cellular ContextR01GM110237 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BEVILACQUA, PHILIP C · 2014 to 2017
$1.1M
NIGMS NIH HHS P41 GM103485NIGMS NIH HHS R01 GM110237NIGMS NIH HHS R35 GM127064
6 · The paper itself

Abstract

Most RNA folding studies have been performed under non-physiological conditions of high concentrations (≥10 mM) of Mg

Indexed as

RNA StabilityAlgorithmsAmino AcidsBase SequenceCatalysisChelating AgentsGlutamatesIonsMagnesiumNucleic Acid ConformationRNARNA, CatalyticRNA FoldingThermodynamicsAmino AcidsChelating AgentsGlutamatesIonsMagnesiumRNARNA, Catalytic

Identifiers

PMID29858572
PMCPMC5984629
OpenAlexW2807593658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.