Evidence map›Paper›PMID 29858487›Full record

ArticleEMBO reports2018

Structural insights into Rhino-Deadlock complex for germline piRNA cluster specification.

Bowen Yu, Yu An Lin, Swapnil S Parhad, Zhaohui Jin, Jinbiao Ma, William E Theurkauf, Zz Zhao Zhang, Ying Huang

Abstract read
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Probing direct interactions between nuclear proteins in cells with nxReLo.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Dichotomous transcriptome divergence at the cell-type level between thebioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. TheeLife · 2022
    Article
  11. A chromodomain protein mediates heterochromatin-directed piRNA expression.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bowen YuState Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Yu An LinDepartment of Embryology, Carnegie Institution for Science, Baltimore, MD, USA.
Swapnil S ParhadProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Zhaohui JinState Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Jinbiao MaState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, China.
William E TheurkaufProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Zz Zhao ZhangDepartment of Embryology, Carnegie Institution for Science, Baltimore, MD, USA zzhang@carnegiescience.edu huangy@sibcb.ac.cn.
Ying HuangState Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China zzhang@carnegiescience.edu huangy@sibcb.ac.cn.ORCID 0000-0002-2806-2874

Funding

RNA localization and translational controlR01HD049116 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI THEURKAUF, WILLIAM EDWARD · 2005 to 2024
$10.8M
Understanding the architecture, regulation, and function of piRNA-producing genesP01HD078253 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ZAMORE, PHILLIP D · 2015 to 2019
$6.5M
Somatic transposition-mediated genome variegation during development, disease and aging conditionsDP5OD021355 · OD · DUKE UNIVERSITY · PI ZHANG, ZHAO · 2015 to 2019
$2.0M
NICHD NIH HHS P01 HD078253NICHD NIH HHS R01 HD049116NIH HHS DP5 OD021355
6 · The paper itself

Abstract

PIWI-interacting RNAs (piRNAs) silence transposons in germ cells to maintain genome stability and animal fertility. Rhino, a rapidly evolving heterochromatin protein 1 (HP1) family protein, binds Deadlock in a species-specific manner and so defines the piRNA-producing loci in the

Indexed as

AnimalsChromosomal Proteins, Non-HistoneCrystallography, X-RayDrosophila melanogasterDrosophila ProteinsGenome, InsectMicrotubule-Associated ProteinsMultiprotein ComplexesRNA, Small InterferingSpecies SpecificityChromosomal Proteins, Non-Histonedel protein, DrosophilaDrosophila ProteinsMicrotubule-Associated ProteinsMultiprotein Complexesrhi protein, DrosophilaRNA, Small Interferingchromoshadow domaincross‐species incompatibilityDeadlockHP1piRNA clusterRhino

Identifiers

PMID29858487
PMCPMC6030695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.