Evidence map›Paper›PMID 29858376›Full record

ArticleMolecular cancer research : MCR2018

Molecular Signature and Mechanisms of Hepatitis D Virus-Associated Hepatocellular Carcinoma.

Giacomo Diaz, Ronald E Engle, Ashley Tice, Marta Melis, Stephanie Montenegro, Jaime Rodriguez-Canales, Jeffrey Hanson, Michael R Emmert-Buck, Kevin W Bock, Ian N Moore and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
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  7. Hepatitis Delta Virus and Hepatocellular Carcinoma.Pathogens (Basel, Switzerland) · 2024
    Review
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  9. Article
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  13. Article
  14. Article
  15. Article
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  18. State of the art treatment of hepatitis B virus hepatocellular carcinoma and the role of hepatitis B surface antigen post-liver transplantation and resection.Liver international : official journal of the International Association for the Study of the Liver · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Giacomo DiazDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Ronald E EngleHepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland.ORCID 0000-0003-4174-1983
Ashley TiceHepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland.
Marta MelisHepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland.
Stephanie MontenegroHepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland.
Jaime Rodriguez-CanalesLaser Capture Microdissection Core Facility, Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland.
Jeffrey HansonLaser Capture Microdissection Core Facility, Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland.
Michael R Emmert-BuckLaser Capture Microdissection Core Facility, Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland.
Kevin W BockInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, Maryland.
Ian N MooreInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, Maryland.
Fausto ZamboniLiver Transplantation Center, Brotzu Hospital, Cagliari, Italy.
Sugantha GovindarajanDepartment of Pathology, Rancho Los Amigos Hospital, University of Southern California, Downey, California.
David E KleinerLaboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland.
Patrizia FarciHepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland. pfarci@niaid.nih.gov.
National Institute of Allergy and Infectious Diseases · USNational Cancer Institute · USAzienda Ospedaliera G. Brotzu · ITRancho Los Amigos National Rehabilitation Center · USUniversity of Cagliari · IT

Funding

Molecular Mechanisms of Pathogenesis of Acute and Chronic Liver DiseasesZIAAI000999 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FARCI, PATRIZIA · 2009 to 2025
$25.3M
Postmortem PathologyZICBC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID ERWIN · 2009 to 2025
$14.3M
Intramural NIH HHS ZIA AI000999Intramural NIH HHS ZIC BC010685
6 · The paper itself

Abstract

There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (

Indexed as

BRCA1 ProteinCarcinoma, HepatocellularDNA, ViralFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Expression Regulation, ViralHepatitis D, ChronicHepatitis Delta VirusHumansLiver NeoplasmsMaleMiddle AgedRNA, ViralBRCA1 ProteinBRCA1 protein, humanDNA, ViralRNA, Viral

Identifiers

PMID29858376
PMCPMC8057128
OpenAlexW2805148515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.