ArticleJournal of the American Heart Association2018
Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery.
Anna Henry Borton, Bryan L Benson, Lee E Neilson, Ashley Saunders, M Amer Alaiti, Alex Y Huang, Mukesh K Jain, Aaron Proweller, Diana L Ramirez-Bergeron
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors at 4 institutions in 1 country.
Anna Henry BortonDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH.
Bryan L BensonDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH.
Lee E NeilsonNeurological Institute, University Hospitals, Cleveland, OH.
Ashley SaundersCase Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH.
M Amer AlaitiCase Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH.
Alex Y HuangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH.
Mukesh K JainCase Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH.
Aaron ProwellerCase Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH.
Diana L Ramirez-BergeronCase Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH dlr36@case.edu.
Case Western Reserve University · USThe Neurological Institute · USUniversity Hospitals of Cleveland · USUniversity School · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
NRSA Training CoreTL1TR002549 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI HARDING, CLIFFORD V · 2018 to 2022
$2.9M
Clinical and Translational Science Collaborative of ClevelandTL1TR000441 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$2.8M
Short term heart, lung, blood research opportunitiesR25HL103152 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MONTANO, MONICA · 2010 to 2024
$2.3M
Mechanisms of hypoxia-induced angiogenic control by vascular smooth muscleR01HL128281 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI PROWELLER, AARON, RAMIREZ-BERGERON, DIANA L · 2016 to 2019
$2.1M
Case Western Reserve University/Cleveland Clinic CTSA (TL1)TL1RR024991 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$2.1M
The Role of ARNT in Endothelial CellsR01HL096597 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI RAMIREZ-BERGERON, DIANA L · 2011 to 2015
$2.0M
Cardiovascular Research Training Program (CRTP)T32HL105338 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR · 2010 to 2014
$1.8M
Training in Neurodegenerative DiseasesT32NS077888 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Xiongwei Zhu · 2013 to 2026
$1.8M
Defining the Role of Hypoxia and HIF in Peripheral Vascular Smooth Muscle CellsF30HL127985 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI BORTON, ANNA HENRY · 2016 to 2017
$98k
Using Microfluidics to Investigate Mechanisms of Leukocyte Intravascular CrawlingF31NS096857 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI BENSON, BRYAN LAUCK · 2017 to 2018
backgroundLimb ischemia resulting from peripheral vascular disease is a common cause of morbidity. Vessel occlusion limits blood flow, creating a hypoxic environment that damages distal tissue, requiring therapeutic revascularization. Hypoxia-inducible factors (HIFs) are key transcriptional regulators of hypoxic vascular responses, including angiogenesis and arteriogenesis. Despite vascular smooth muscle cells' (VSMCs') importance in vessel integrity, little is known about their functional responses to hypoxia in peripheral vascular disease. This study investigated the role of VSMC HIF in mediating peripheral ischemic responses. METHODS AND
resultsWe used
conclusionsOur data demonstrate that traditional vascular remodeling responses are insufficient to provide robust peripheral tissue reperfusion in
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery. · full record | OpenQuestion