Evidence map›Paper›PMID 29858360›Full record

ArticleJournal of the American Heart Association2018

Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model.

Claire L Curl, Vennetia R Danes, James R Bell, Antonia J A Raaijmakers, Wendy T K Ip, Chanchal Chandramouli, Tristan W Harding, Enzo R Porrello, Jeffrey R Erickson, Fadi J Charchar and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  14. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Article
  15. Effects of Sarcolemmal Background CaFrontiers in physiology · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. NETosis as a Pathogenic Factor for Heart Failure.Oxidative medicine and cellular longevity · 2021
    Review
  20. RyR2 and Calcium Release in Heart Failure.Frontiers in physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Claire L CurlDepartment of Physiology, University of Melbourne, Victoria, Australia.
Vennetia R DanesDepartment of Physiology, University of Melbourne, Victoria, Australia.
James R BellDepartment of Physiology, University of Melbourne, Victoria, Australia.
Antonia J A RaaijmakersDepartment of Physiology, University of Melbourne, Victoria, Australia.
Wendy T K IpDepartment of Physiology, University of Melbourne, Victoria, Australia.
Chanchal ChandramouliDepartment of Physiology, University of Melbourne, Victoria, Australia.
Tristan W HardingDepartment of Physiology, University of Melbourne, Victoria, Australia.
Enzo R PorrelloDepartment of Physiology, University of Melbourne, Victoria, Australia.
Jeffrey R EricksonDepartment of Physiology, University of Otago, Dunedin, New Zealand.
Fadi J CharcharSchool of Applied & Biomedical Sciences, Federation University, Ballarat, Australia.
Andrew R KompaDepartment of Medicine, St. Vincent's Hospital The University of Melbourne, Australia.
Amanda J EdgleyDepartment of Medicine, St. Vincent's Hospital The University of Melbourne, Australia.
David J CrossmanDepartment of Physiology, University of Auckland, New Zealand.
Christian SoellerBiomedical Physics, University of Exeter, United Kingdom.
Kimberley M MellorDepartment of Physiology, University of Melbourne, Victoria, Australia.
Jonathan M KalmanDepartment of Medicine, University of Melbourne, Victoria, Australia.
Stephen B HarrapDepartment of Physiology, University of Melbourne, Victoria, Australia.
Lea M D DelbridgeDepartment of Physiology, University of Melbourne, Victoria, Australia lmd@unimelb.edu.au.
University of Melbourne · AUSt Vincent's Hospital · AUFederation University · AUUniversity of Auckland · NZUniversity of Exeter · GBUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong the growing numbers of patients with heart failure, up to one half have heart failure with preserved ejection fraction (HFpEF). The lack of effective treatments for HFpEF is a substantial and escalating unmet clinical need-and the lack of HFpEF-specific animal models represents a major preclinical barrier in advancing understanding of HFpEF. As established treatments for heart failure with reduced ejection fraction (HFrEF) have proven ineffective for HFpEF, the contention that the intrinsic cardiomyocyte phenotype is distinct in these 2 conditions requires consideration. Our goal was to validate and characterize a new rodent model of HFpEF, undertaking longitudinal investigations to delineate the associated cardiac and cardiomyocyte pathophysiology. METHODS AND

resultsThe selectively inbred Hypertrophic Heart Rat (HHR) strain exhibits adult cardiac enlargement (without hypertension) and premature death (40% mortality at 50 weeks) compared to its control strain, the normal heart rat. Hypertrophy was characterized in vivo by maintained systolic parameters (ejection fraction at 85%-90% control) with marked diastolic dysfunction (increased E/E'). Surprisingly, HHR cardiomyocytes were hypercontractile, exhibiting high Ca

conclusionsThus, the cardiomyocyte remodeling process in the etiology of this HFpEF model contrasts dramatically with the suppressed Ca

Indexed as

AnimalsCalciumDisease Models, AnimalEchocardiography, DopplerElectrocardiographyHeart FailureHeart VentriclesImmunoblottingMyocardial ContractionMyocytes, CardiacPatch-Clamp TechniquesRats, Inbred F344Stroke VolumeCalciumcalcium handlingcardiaccardiomyocytefibrosisheart failure preserved ejection fractionhypertrophy

Identifiers

PMID29858360
PMCPMC6015350
OpenAlexW2806524607

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.