Evidence map›Paper›PMID 29857561›Full record

ReviewViruses2018

Baculovirus Surface Display of Immunogenic Proteins for Vaccine Development.

Balraj Premanand, Poh Zhong Wee, Mookkan Prabakaran

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Balraj PremanandTemasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604, Singapore. prem@tll.org.sg.
Poh Zhong WeeTemasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604, Singapore. pohzhongwee@gmail.com.
Mookkan PrabakaranTemasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604, Singapore. prabakar@tll.org.sg.ORCID 0000-0002-9816-5908
Temasek Life Sciences Laboratory · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination is an efficient way to prevent the occurrence of many infectious diseases in humans. To date, several viral vectors have been utilized for the generation of vaccines. Among them, baculovirus-categorized as a nonhuman viral vector-has been used in wider applications. Its versatile features, like large cloning capacity, nonreplicative nature in mammalian cells, and broad tissue tropism, hold it at an excellent position among vaccine vectors. In addition to ease and safety during swift production, recent key improvements to existing baculovirus vectors (such as inclusion of hybrid promoters, immunostimulatory elements, etc.) have led to significant improvements in immunogenicity and efficacy of surface-displayed antigens. Furthermore, some promising preclinical results have been reported that mirror the scope and practicality of baculovirus as a vaccine vector for human applications in the near future. Herein, this review provides an overview of the induced immune responses by baculovirus surface-displayed vaccines against influenza and other infectious diseases in animal models, and highlights the strategies applied to enhance the protective immune responses against the displayed antigens.

Indexed as

Genetic VectorsAnimalsAntibodies, ViralAntigensBaculoviridaeCell Surface Display TechniquesDisease Models, AnimalHumansInfluenza VaccinesMiceProteinsRecombinant ProteinsAntibodies, ViralAntigensInfluenza VaccinesProteinsRecombinant Proteinsinfectious diseasesrecombinant baculovirussurface displayvaccine

Identifiers

PMID29857561
PMCPMC6024371
OpenAlexW2805642866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.