Evidence map›Paper›PMID 29857515›Full record

ReviewInternational journal of molecular sciences2018

Bacterial Toxins and Targeted Brain Therapy: New Insights from Cytotoxic Necrotizing Factor 1 (CNF1).

Elena Tantillo, Antonella Colistra, Eleonora Vannini, Chiara Cerri, Laura Pancrazi, Laura Baroncelli, Mario Costa, Matteo Caleo

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Contribution of pks+Microorganisms · 2024
    Review
  4. Review
  5. Bacteria associated with glioma: a next wave in cancer treatment.Frontiers in cellular and infection microbiology · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Elena TantilloCNR Neuroscience Institute, via G. Moruzzi 1, 56124 Pisa, Italy. e.tantillo@fpscience.it.
Antonella ColistraCNR Neuroscience Institute, via G. Moruzzi 1, 56124 Pisa, Italy. anto_colistra@yahoo.it.
Eleonora VanniniCNR Neuroscience Institute, via G. Moruzzi 1, 56124 Pisa, Italy. e.vannini@in.cnr.it.
Chiara CerriCNR Neuroscience Institute, via G. Moruzzi 1, 56124 Pisa, Italy. c.cerri@in.cnr.it.
Laura PancraziCNR Neuroscience Institute, via G. Moruzzi 1, 56124 Pisa, Italy. laura.pancrazi@sns.it.
Laura BaroncelliCNR Neuroscience Institute, via G. Moruzzi 1, 56124 Pisa, Italy. baroncelli@in.cnr.it.
Mario CostaCNR Neuroscience Institute, via G. Moruzzi 1, 56124 Pisa, Italy. costa@in.cnr.it.
Matteo CaleoCNR Neuroscience Institute, via G. Moruzzi 1, 56124 Pisa, Italy. caleo@in.cnr.it.ORCID 0000-0002-4333-6378
Neuroscience Institute · ITFondazione Pisa · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic bacteria produce toxins to promote host invasion and, therefore, their survival. The extreme potency and specificity of these toxins confer to this category of proteins an exceptionally strong potential for therapeutic exploitation. In this review, we deal with cytotoxic necrotizing factor (CNF1), a cytotoxin produced by

Indexed as

Molecular Targeted TherapyAnimalsAntineoplastic AgentsBacterial ToxinsBrain DiseasesEscherichia coli ProteinsGene Expression RegulationHumansNeuronsSignal TransductionStructure-Activity RelationshipAntineoplastic AgentsBacterial Toxinscytotoxic necrotizing factor type 1Escherichia coli Proteinscerebral cortexCNF1gliomaplasticityRho GTPases

Identifiers

PMID29857515
PMCPMC6032336
OpenAlexW2806640330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.