ArticlePloS one2018
A comprehensive understanding of the biocontrol potential of Bacillus velezensis LM2303 against Fusarium head blight.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed.
- Bacilli the most important biocontrol agent in Brazilian agriculture: from mechanisms of action to market adoption.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Review
- Harnessing an endophytic Bacillus strain closely related to Bacillus velezensis for biocontrol of twig blight in bayberry caused by Pestalotiopsis versicolor.BMC plant biology · 2026Article
- Whole-genome analysis reveals the growth-promoting and biocontrol potential of Bacillus amyloliquefaciens Ba. YN.J3 isolated from Avena Sativa.BMC genomics · 2026Article
- Genomic insights into three Bacillus strains for biocontrol of tobacco black shank disease.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Genomic characterization ofFrontiers in microbiology · 2026Article
- The composting microbiome and a multifunctionalFrontiers in microbiology · 2026Article
- Genomic sequencing of vineyard-isolatedFrontiers in microbiology · 2026Article
- Characterization ofInternational journal of molecular sciences · 2025Article
- Genome-Guided Identification and Characterisation of Broad-Spectrum Antimicrobial Compounds of Bacillus velezensis Strain PD9 Isolated from Stingless Bee Propolis.Probiotics and antimicrobial proteins · 2025Article
- Microorganisms as Potential Accelerators of Speed Breeding: Mechanisms and Knowledge Gaps.Plants (Basel, Switzerland) · 2025Review
- Antagonistic mechanism ofApplied and environmental microbiology · 2025Article
- Genomically-selected antifungal Bacillaceae strains improve wheat yield and baking quality.Applied microbiology and biotechnology · 2025Article
- Genomic Analysis and Metabolite Profiling of Three ProbioticPreventive nutrition and food science · 2025Article
- Optimization of endospore production by solid and liquid fermentation for the development of effective formulations of Bacillus velezensis-based products.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Antagonism of Bacillus velezensis ZGE166 Against the Pathogenic Fungi Causing Corm Rot Disease in Saffron (Crocus sativus L.).Microbial ecology · 2025Article
- Pharmacological assessment of the extract and a novel compound of Bacillus velezensis DM derived from the rhizosphere of Datura metel L. with microbial molecular screening.BMC complementary medicine and therapies · 2025Article
- β-(1 → 3) Linked Sulfated Polygalactan from a Seaweed-associated Bacillus velezensis MTCC 13097: A Potential Lead Against Human Hepatocellular Adenocarcinoma.Marine biotechnology (New York, N.Y.) · 2025Article
- Efficacy of Selected Bacterial Strains in the Protection and Growth Stimulation of Winter Wheat and Maize.Plants (Basel, Switzerland) · 2025Article
- Enhancing Antifungal Drug Discovery Through Co-Culture with AntarcticInternational journal of molecular sciences · 2024Article
- Antifungal Activity of Rhizosphere Bacillus Isolated fromMicroorganisms · 2024Article
20 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Fusarium head blight (FHB) mainly caused by F. graminearum, always brings serious damage to wheat production worldwide. In this study, we found that strain LM2303 had strong antagonist activity against F. graminearum and significantly reduced disease severity of FHB with the control efficiency of 72.3% under field conditions. To gain a comprehensive understanding of the biocontrol potential of strain LM2303 against FHB, an integrated approach of genome mining and chemical analysis was employed. The whole genome of strain LM2303 was obtained and analyzed, showing the largest number of genes/gene clusters associated with biocontrol functions as compared with the known biocontrol strains (FZB42, M75, CAU B946). And strain LM2303 was accurately determined as a member of the B. velezensis clade using the phylogenomic analysis of single-copy core genes. Through genome mining, 13 biosynthetic gene clusters(BGCs) encoding secondary metabolites with biocontrol functions were identified, which were further confirmed through chemical analyses such as UHPLC-ESI-MS, including three antifungal metabolites (fengycin B, iturin A, and surfactin A), eight antibacterial metabolites (surfactin A, butirosin, plantazolicin and hydrolyzed plantazolicin, kijanimicin, bacilysin, difficidin, bacillaene A and bacillaene B, 7-o-malonyl macrolactin A and 7-o-succinyl macrolactin A), the siderophore bacillibactin, molybdenum cofactor and teichuronic acid. In addition, genes/gene clusters involved in plant colonization, plant growth promotion and induced systemic resistance were also found and analyzed, along with the corresponding metabolites. Finally, four different mechanisms of strain LM2303 involved in the biocontrol of FHB were putatively obtained. This work provides better insights into a mechanistic understanding of strain LM2303 in control of FHB, reinforcing the higher potential of this strain as a powerful biocontrol strain agent (BCA) for FHB control. The results also provide scientific reference and comparison for other biocontrol strains.
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