ArticlePloS one2018
Lateral orbitofrontal cortex partitions mechanisms for fear regulation and alcohol consumption.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- BDNF in ventrolateral orbitofrontal cortex to dorsolateral striatum circuit moderates alcohol consumption, seeking and relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Paraventricular thalamic inputs to the ventral pallidum shape reward seeking during threat and fear responding in extinction.Behavioral neuroscience · 2025Article
- Age and sex independently influence safety learning in mice.Behavioural brain research · 2025Article
- Orbitofrontal and Prelimbic Cortices Serve Complementary Roles in Adapting Reward Seeking to Learned Anxiety.Biological psychiatry · 2024Article
- Adapting to Changes in Communication: The Orbitofrontal Cortex in Language and Speech Processing.Brain sciences · 2024Review
- Brainstem networks construct threat probability and prediction error from neuronal building blocks.Nature communications · 2022Article
- Orbitofrontal cortex subregion inhibition during binge-like and aversion-resistant alcohol drinking.Alcohol (Fayetteville, N.Y.) · 2022Article
- Aberrant orbitofrontal cortical activation interferes with encoding of Pavlovian fear conditioning.Frontiers in behavioral neuroscience · 2022Article
- Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- Retrorubral field is a hub for diverse threat and aversive outcome signals.Current biology : CB · 2021Article
- Foot shock facilitates reward seeking in an experience-dependent manner.Behavioural brain research · 2021Article
- Absence Makes the Mind Grow Fonder: Reconceptualizing Studies of Safety Learning in Translational Research on Anxiety.Cognitive, affective & behavioral neuroscience · 2021Review
- Neural correlates of safety learning.Behavioural brain research · 2021Article
- Early adolescent adversity alters periaqueductal gray/dorsal raphe threat responding in adult female rats.Scientific reports · 2020Article
- Chemogenetic Inactivation of Orbitofrontal Cortex Decreases Cue-induced Reinstatement of Ethanol and Sucrose Seeking in Male and Female Wistar Rats.Alcoholism, clinical and experimental research · 2020Article
- Article
- The Nucleus Accumbens Core is Necessary to Scale Fear to Degree of Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The ventrolateral periaqueductal grey updates fear via positive prediction error.The European journal of neuroscience · 2020Article
- Ventrolateral periaqueductal gray neurons prioritize threat probability over fear output.eLife · 2019Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
Anxiety disorders and alcohol use disorder are highly comorbid, yet identifying neural dysfunction driving comorbidity has been challenging. Lateral orbitofrontal cortex (lOFC) dysfunction has been independently observed in each disorder. Here we tested the hypothesis that the lOFC is essential to partition mechanisms for fear regulation and alcohol consumption. Specifically, the capacity to regulate fear and the propensity to consume alcohol are unrelated when lOFC is intact, but become linked through lOFC dysfunction. Male Long Evans rats received bilateral, neurotoxic lOFC lesions or sham surgery. Fear regulation was determined by establishing discrimination to danger, uncertainty, and safety cues then shifting the shock probability of the uncertainty cue. Alcohol consumption was assessed through voluntary, intermittent access to 20% ethanol. The neurotoxic lesion approach ensured lOFC dysfunction spanned testing in fear regulation and alcohol consumption. LOFC-lesioned rats demonstrated maladaptive fear generalization during probability shifts, inverting normal prediction error assignment, and subsequently consumed more alcohol. Most novel, fear regulation and alcohol consumption were inextricably linked only in lOFC-lesioned rats: extreme fear regulation predicted excessive alcohol consumption. The results reveal the lOFC is essential to partition mechanisms for fear regulation and alcohol consumption and uncover a plausible source of neural dysfunction contributing to comorbid anxiety disorders and alcohol use disorder.
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