ReviewChemical Society reviews2018
Development of endogenous enzyme-responsive nanomaterials for theranostics.
Review in Chemical Society reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 368 citations in OpenAlex.
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- Versatile metal-phenolic network structure (MPNs) as advanced delivery platforms for bioactive compounds: The design principles, foundations, applications, and future perspectives.Materials today. Bio · 2026Review
- Electric Field-Empowered Nanozymes: From Passive Adaptation to Active Precision Therapy.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Activatable NIR Schaap's 1,2-Dioxetane-Based Chemiluminescent Probes for Bioimaging Applications.Chemical & biomedical imaging · 2026Review
- Multifunctional fiber-optic theranostic probe for closed-loop tumor photothermal therapy.Light, science & applications · 2026Article
- AND-Logic-Based Dual-Lock Hemicyanine Fluorescence Probe for Accurate Hypoxia Assessment in Tumors.Chemical & biomedical imaging · 2026Article
- Electro-Stimulated Graphene-Polymer Nanocomposites Enable Wearable Patches With Feedback-Controlled Drug Release.Advanced healthcare materials · 2026Article
- From conceptual design to translational progress: Emerging advances in intelligent microneedles for biomedical applications.Acta pharmaceutica Sinica. B · 2026Review
- Biomarker-Guided Drug Delivery Systems and Oral Bioavailability Enhancement.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Research review of enzyme-responsive packaging in food preservation.Food science and biotechnology · 2026Review
- Review
- Smart nanoparticle delivery systems for curcumin: a targeted strategy to enhance anticancer efficacy and bioavailability.Journal of materials science. Materials in medicine · 2026Review
- Nanoparticle Drug Delivery Systems: The Future Direction for the Treatment of Tumors.International journal of nanomedicine · 2026Review
- Cellulose Nanocrystal-Based Sulfatase-Responsive Hydrogel for Sustained Celecoxib Release in Ulcerative Colitis Therapy.Biomaterials research · 2026Article
- Antibacterial hydrogels for skin infected wounds: frontier approaches as antibiotic alternatives therapy.Frontiers in cellular and infection microbiology · 2026Review
- Chemical probes for enzyme imaging: challenges in design, synthesis and biomedical applications.Chemical science · 2025Review
- Unimer Exchange as a Tool for Programming Enzymatic Degradation through Micellar Dynamics.Biomacromolecules · 2025Article
- Hydrogel Microspheres as Versatile Platforms for Biomedical Research: Design, Properties, and Applications.MedComm · 2025Review
- Site-specific adaptive nanovesicles for oral insulin delivery.Science advances · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 4 countries.
Funding
Abstract
The development of stimuli-responsive nanomaterials provides great potential for accurate diagnosis, effective treatment and precision theranostics. Among the sources of endogenous stimuli (e.g. enzymes, pH, redox, hypoxia, etc.) and exogenous stimuli (e.g. temperature, light, magnetic field, ultrasound, light, etc.), enzymes with intrinsic merits such as high relevance for numerous diseases, specific substrate selectivity and high catalytic efficiency have been widely employed for the design of responsive materials. The catalytic mechanisms mainly include the reduction/oxidation of substrates and the formation/cleavage of chemical bonds. So far, many enzymes such as proteases, phosphatases, kinases and oxidoreductases have been used in stimuli-responsive nanomaterials for theranostics. This tutorial review summarizes the recent progress in endogenous enzyme-responsive nanomaterials based on different building blocks such as polymers, liposomes, small organic molecules, or inorganic/organic hybrid materials; their design principles are also elaborated. In the end, the challenges and prospects of enzyme-responsive biomaterials-based theranostics are also discussed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.