ArticleJournal of clinical neurology (Seoul, Korea)2018
Sympathetic Overactivity Based on Heart-Rate Variability in Patients with Obstructive Sleep Apnea and Cerebral Small-Vessel Disease.
Article in Journal of clinical neurology (Seoul, Korea), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Predicting All-Cause Mortality in Patients With Obstructive Sleep Apnea Using Sleep-Related Features: A Machine-Learning Approach.Journal of clinical neurology (Seoul, Korea) · 2025Article
- Differential analysis of clinical outcomes in cerebral infarction associated with REM-OSA and NREM-OSA: a retrospective database study.Frontiers in neurology · 2025Article
- Blood urea nitrogen to albumin ratio is associated with cerebral small vessel diseases.Scientific reports · 2024Article
- Impact of CPAP Therapy on the Autonomic Nervous System.Biomedicines · 2023Article
- Implication of heart rate variability on cerebral small vessel disease: A potential therapeutic target.CNS neuroscience & therapeutics · 2023Article
- Autonomic Dysfunction in Sleep Disorders: From Neurobiological Basis to Potential Therapeutic Approaches.Journal of clinical neurology (Seoul, Korea) · 2022Review
- Relationship between sleep disorders and the prognosis of neurological function after stroke.Frontiers in neurology · 2022Article
- Relationship between heart rate variability and cognitive function in patients with enlarged perivascular space.Frontiers in aging neuroscience · 2022Article
- Decreased nocturnal heart rate variability and potentially related brain regions in arteriosclerotic cerebral small vessel disease.BMC neurology · 2021Article
- A two-sample Mendelian randomization analysis of heart rate variability and cerebral small vessel disease.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Dynamic changes in nocturnal blood glucose levels are associated with sleep-related features in patients with obstructive sleep apnea.Scientific reports · 2020Article
- Autonomic function in amnestic and non-amnestic mild cognitive impairment: spectral heart rate variability analysis provides evidence for a brain-heart axis.Scientific reports · 2020Article
- Interarm Blood Pressure Difference has Various Associations with the Presence and Burden of Cerebral Small-Vessel Diseases in Noncardioembolic Stroke Patients.Journal of clinical neurology (Seoul, Korea) · 2019Article
- The Association of Autonomic Nervous System Function With Ischemic Stroke, and Treatment Strategies.Frontiers in neurology · 2019Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeObstructive sleep apnea (OSA) is associated with cerebral white-matter changes (WMC), but the underlying mechanisms are not completely understood. Our aim was to identify the cardiovascular autonomic characteristics during sleep that are associated with cerebral WMC in OSA patients.
methodsWe recruited subjects from our sleep-center database who underwent both polysomnography and brain MRI within a 1-year period. Sixty patients who had OSA with WMC (OSA+WMC), 44 patients who had OSA without WMC (OSA-WMC), and 31 control subjects who had neither OSA nor WMC were analyzed. Linear and nonlinear indices of heart-rate variability (HRV) were analyzed in each group according to different sleep stages and also over the entire sleeping period.
resultsAmong the nonlinear HRV indices, the Poincaré ratio (SD12) during the entire sleep period was significantly increased in the OSA+WMC group, even after age adjustment. Meanwhile, detrended fluctuation analysis 1 during non-rapid-eye-movement sleep tended to be lowest in the OSA+WMC group. These indices were altered regardless of the presence of hypertension or diabetes. In the subgroup analysis of middle-aged OSA patients, approximate entropy during rapid-eye-movement sleep was significantly lower in OSA+WMC patients than in OSA-WMC patients. Overall, the nonlinear HRV indices suggest that sympathetic activity was higher in the OSA+WMC group than in the OSA-WMC and control groups.
conclusionsOur findings suggest that dysregulation of HRV, especially overactivation of sympathetic tone, could be a pathophysiologic mechanism underlying the development of WMC in OSA patients.
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